eF-site ID 4ri5-AB PDB Code 4ri5 Chain A, B click to enlarge Title Crystal structure of PTPN3 (PTPH1) D811E mutant in complex with metavanadate Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 3 Source (PTN3_HUMAN) Sequence A:  SNADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT TLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYV SREMLVTNTQTGEEHTVTHLQYVAWPEHGVPDDSSDFLEF VNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTER NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE GLVQ B:  SNADTLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITF AKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT TLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYV SREMLVTNTQTGEEHTVTHLQYVAWPEHGVPDDSSDFLEF VNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTER NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE GLVQ Description Functional site 1) chain A residue 812 type sequence H description BINDING SITE FOR RESIDUE GOL A 1001 source : AC1 2) chain A residue 886 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1001 source : AC1 3) chain A residue 842 type sequence C description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 4) chain A residue 843 type sequence S description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 5) chain A residue 844 type sequence A description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 6) chain A residue 845 type sequence G description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 7) chain A residue 846 type sequence I description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 8) chain A residue 847 type sequence G description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 9) chain A residue 848 type sequence R description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 10) chain A residue 886 type sequence Q description BINDING SITE FOR RESIDUE VN4 A 1002 source : AC2 11) chain B residue 676 type sequence Y description BINDING SITE FOR RESIDUE GOL B 1001 source : AC3 12) chain B residue 812 type sequence H description BINDING SITE FOR RESIDUE GOL B 1001 source : AC3 13) chain B residue 886 type sequence Q description BINDING SITE FOR RESIDUE GOL B 1001 source : AC3 14) chain B residue 842 type sequence C description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 15) chain B residue 843 type sequence S description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 16) chain B residue 844 type sequence A description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 17) chain B residue 845 type sequence G description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 18) chain B residue 846 type sequence I description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 19) chain B residue 847 type sequence G description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 20) chain B residue 848 type sequence R description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 21) chain B residue 886 type sequence Q description BINDING SITE FOR RESIDUE VN4 B 1002 source : AC4 22) chain A residue 811 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 23) chain A residue 842 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 886 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 25) chain B residue 811 type BINDING sequence E description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 842 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 27) chain B residue 886 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 28) chain A residue 842 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 842 type ACT_SITE sequence C description Phosphocysteine intermediate => ECO:0000255|PROSITE-ProRule:PRU00160, ECO:0000255|PROSITE-ProRule:PRU10044 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 840-850 type prosite sequence VHCSAGIGRTG description TYR_PHOSPHATASE_1 Tyrosine specific protein phosphatases active site. VHCsaGigRTG source prosite : PS00383

Display surface Download Links