eF-site ID 4rch-A PDB Code 4rch Chain A click to enlarge Title Discovery of 2-Pyridyl Ureas as Glucokinase Activators Classification TRANSFERASE Compound Glucokinase Source (HXK4_HUMAN) Sequence A:  TLVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEA SVKMLPTYVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGE GEEGQWSVKTKHQMYSIPEDAMTGTAEMLFDYISECISDF LDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKA SGAEGNNVVGLLRDAIKRRGDFEMDVVAMVNDTVATMISC YYEDHQCEVGMIVGTGCNACYMEEMQNVELVEGDEGRMCV NTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLI GGKYMGELVRLVLLRLVDENLLFHGEASEQLRTRGAFETR FVSQVESDTGDRKQIYNILSTLGLRPSTTDCDIVRRACES VSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVY KLHPSFKERFHASVRRLTPSCEITFIESEEGSGRGAALVS AVACKKAC Description Functional site 1) chain A residue 169 type catalytic sequence K description 592 source MCSA : MCSA1 2) chain A residue 205 type catalytic sequence D description 592 source MCSA : MCSA1 3) chain A residue 146-171 type prosite sequence LGFTFSFPVRHEDIDKGILLNWTKGF description HEXOKINASE_1 Hexokinase domain signature. LGFTFSFPvrhedIDkgiLlnWTKgF source prosite : PS00378 4) chain A residue 78 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:P19367 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 151 type BINDING sequence S description BINDING => ECO:0000269|PubMed:15016359 source Swiss-Prot : SWS_FT_FI2 6) chain A residue 168 type BINDING sequence T description BINDING => ECO:0000269|PubMed:15016359 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 204 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016359 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 231 type BINDING sequence N description BINDING => ECO:0000269|PubMed:15016359 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 256 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15016359 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 290 type BINDING sequence E description BINDING => ECO:0000269|PubMed:15016359 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 228 type BINDING sequence T description BINDING => ECO:0000269|PubMed:22101819, ECO:0007744|PDB:3FGU, ECO:0007744|PDB:3ID8 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 295 type BINDING sequence G description BINDING => ECO:0000269|PubMed:22101819, ECO:0007744|PDB:3FGU, ECO:0007744|PDB:3ID8 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 332 type BINDING sequence T description BINDING => ECO:0000269|PubMed:22101819, ECO:0007744|PDB:3FGU, ECO:0007744|PDB:3ID8 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 411 type BINDING sequence S description BINDING => ECO:0000269|PubMed:22101819, ECO:0007744|PDB:3FGU, ECO:0007744|PDB:3ID8 source Swiss-Prot : SWS_FT_FI3

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