eF-site ID 4r7g-A PDB Code 4r7g Chain A click to enlarge Title Determination of the formylglycinamide ribonucleotide amidotransferase ammonia pathway by combining 3D-RISM theory with experiment Classification LIGASE Compound Phosphoribosylformylglycinamidine synthase Source Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (PUR4_SALTY) Sequence A:  GLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQVHN IYAEYVHFADLNAPLNDSEQAQLTRLLQYGPALSSHTPAG KLLLVTPRPGTISPWSSKATDIAHNCGLQQVDRLERGVAY YIEASTLTAEQWRQVAAELHDRMMETVFSSLTDAEKLFIH HQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYLQE AFTKLGRNPNDIELYMFAQANSEHCRHKIFNADWIIDGKP QPKSLFKMIKNTFETTPDYVLSAYKDNAAVMEGSAVGRYF ADHNTGRYDFHQEPAHILMKVETHNHPTAISPWPGAATGS GGEIRDEGATGRGAKPKAGLIGFSVSNLRIPGFEQPWEED FGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFRTY EEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEIVV GAKLIVLGGPAMNIGFASVQRDNPEMERRCQEVIDRCWQL GDANPILFIHDVGAGGLSNAMPELVSDGGRGGKFELRDIL SDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELCKRER APYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLGKTPK MTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVAEKTF LVTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASLDSYY GEAMSIGERAPVALLDFAASARLAVGEALTNIAATQIGDI KRIKLSANWMAAAGHPGEDAGLYDAVKAVGEELCPQLGLT IPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFARVEDV RHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVYRQLG DKPADVRDVAQLKGFYDAMQALVAARKLLAWHDRSDGGLL VTLAEMAFAGHCGVQVDIAALGDDHLAALFNEELGGVIQV RAEDRDAVEALLAQYGLADCVHYLGQALAGDRFVITANDQ TVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHEAKAN DTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLREQGVN SHVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHALVAC GGFSYGDVLGAGEGWAKSILFNHRVRDEFETFFHRPQTLA LGVXNGCQMMSNLRELIPGSELWPRFVRNHSDRFEARFSL VEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDAHLAA LESKGLVALRYVDNFGKVTETYPANPNGSPNGITAVTTEN GRVTIMMPHPERVFRTVANSWHPENWGEDSPWMRIFRNAR KQLG Description Functional site 1) chain A residue 679 type sequence D description BINDING SITE FOR RESIDUE MG A 1301 source : AC1 2) chain A residue 722 type sequence N description BINDING SITE FOR RESIDUE MG A 1301 source : AC1 3) chain A residue 884 type sequence D description BINDING SITE FOR RESIDUE MG A 1301 source : AC1 4) chain A residue 886 type sequence S description BINDING SITE FOR RESIDUE MG A 1301 source : AC1 5) chain A residue 697 type sequence I description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 6) chain A residue 718 type sequence E description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 7) chain A residue 896 type sequence E description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 8) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1304 source : AC4 9) chain A residue 294 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1304 source : AC4 10) chain A residue 504 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1304 source : AC4 11) chain A residue 505 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1304 source : AC4 12) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 13) chain A residue 295 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 14) chain A residue 296 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 15) chain A residue 297 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 16) chain A residue 298 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 17) chain A residue 778 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 18) chain A residue 812 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 19) chain A residue 1228 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 20) chain A residue 1229 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 21) chain A residue 1176 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 22) chain A residue 1183 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 23) chain A residue 1184 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 24) chain A residue 1185 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 25) chain A residue 1186 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 26) chain A residue 1040 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1308 source : AC8 27) chain A residue 1041 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1308 source : AC8 28) chain A residue 1086 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1308 source : AC8 29) chain A residue 1086 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 30) chain A residue 1126 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 31) chain A residue 1127 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 32) chain A residue 1128 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 33) chain A residue 333 type sequence I description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 34) chain A residue 386 type sequence T description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 35) chain A residue 387 type sequence G description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 36) chain A residue 388 type sequence Y description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 37) chain A residue 389 type sequence F description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 38) chain A residue 649 type sequence K description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 39) chain A residue 652 type sequence L description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 40) chain A residue 653 type sequence V description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 41) chain A residue 668 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 42) chain A residue 676 type sequence P description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 43) chain A residue 678 type sequence A description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 44) chain A residue 679 type sequence D description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 45) chain A residue 718 type sequence E description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 46) chain A residue 722 type sequence N description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 47) chain A residue 886 type sequence S description BINDING SITE FOR RESIDUE ADP A 1310 source : BC1 48) chain A residue 1135 type ACT_SITE sequence X description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI1 49) chain A residue 1260 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI2 50) chain A residue 1262 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI2 51) chain A residue 307 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI3 52) chain A residue 386 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI4 53) chain A residue 678 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI4 54) chain A residue 886 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI4 55) chain A residue 679 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5 56) chain A residue 718 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5 57) chain A residue 722 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5 58) chain A residue 884 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5

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