eF-site ID 4r4q-A
PDB Code 4r4q
Chain A

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Title Crystal structure of RPA70N in complex with 5-(3-((N-(4-(5-carboxyfuran-2-yl)benzyl)acetamido)methyl)phenyl)-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylic acid
Classification PROTEIN BINDING
Compound Replication protein A 70 kDa DNA-binding subunit
Source Homo sapiens (Human) (RFA1_HUMAN)
Sequence A:  HMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGNSP
PRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVCQI
HRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVPYN
E
Description


Functional site

1) chain A
residue 33
type
sequence I
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

2) chain A
residue 34
type
sequence T
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

3) chain A
residue 41
type
sequence R
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

4) chain A
residue 55
type
sequence S
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

5) chain A
residue 57
type
sequence M
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

6) chain A
residue 59
type
sequence A
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

7) chain A
residue 60
type
sequence T
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

8) chain A
residue 85
type
sequence N
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

9) chain A
residue 87
type
sequence L
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

10) chain A
residue 91
type
sequence R
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

11) chain A
residue 93
type
sequence V
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

12) chain A
residue 95
type
sequence I
description BINDING SITE FOR RESIDUE 3HZ A 201
source : AC1

13) chain A
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
source Swiss-Prot : SWS_FT_FI1

14) chain A
residue 88
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 22
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068
source Swiss-Prot : SWS_FT_FI2


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