eF-site ID 4qz0-b PDB Code 4qz0 Chain b click to enlarge Title yCP beta5-M45V mutant in complex with the epoxyketone inhibitor ONX 0914 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence b:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL Description Functional site 1) chain b residue 1 type sequence T description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 2) chain b residue 20 type sequence T description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 3) chain b residue 21 type sequence T description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 4) chain b residue 22 type sequence T description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 5) chain b residue 45 type sequence R description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 6) chain b residue 46 type sequence S description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 7) chain b residue 47 type sequence G description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 8) chain b residue 49 type sequence A description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 9) chain b residue 168 type sequence S description BINDING SITE FOR RESIDUE 04C b 201 source : BC9 10) chain b residue 4-51 type prosite sequence MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC CRSGSAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD source prosite : PS00854 11) chain b residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1

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