eF-site ID 4qz0-V PDB Code 4qz0 Chain V click to enlarge Title yCP beta5-M45V mutant in complex with the epoxyketone inhibitor ONX 0914 Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence V:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICD Description Functional site 1) chain V residue 69 type sequence Y description BINDING SITE FOR RESIDUE CL U 301 source : BC1 2) chain V residue 1 type sequence T description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 3) chain V residue 19 type sequence R description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 4) chain V residue 20 type sequence S description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 5) chain V residue 21 type sequence T description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 6) chain V residue 22 type sequence Q description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 7) chain V residue 31 type sequence C description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 8) chain V residue 45 type sequence G description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 9) chain V residue 47 type sequence G description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 10) chain V residue 48 type sequence T description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 11) chain V residue 49 type sequence A description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 12) chain V residue 52 type sequence T description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 13) chain V residue 53 type sequence E description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 14) chain V residue 168 type sequence G description BINDING SITE FOR RESIDUE 04C V 301 source : BC2 15) chain V residue 163 type sequence I description BINDING SITE FOR RESIDUE MG V 302 source : BC3 16) chain V residue 164 type sequence W description BINDING SITE FOR RESIDUE MG V 302 source : BC3 17) chain V residue 166 type sequence D description BINDING SITE FOR RESIDUE MG V 302 source : BC3 18) chain V residue 167 type sequence L description BINDING SITE FOR RESIDUE MG V 302 source : BC3 19) chain V residue 169 type sequence S description BINDING SITE FOR RESIDUE MG V 302 source : BC3 20) chain V residue 47 type sequence G description BINDING SITE FOR RESIDUE MES V 303 source : BC4 21) chain V residue 128 type sequence G description BINDING SITE FOR RESIDUE MES V 303 source : BC4 22) chain V residue 129 type sequence S description BINDING SITE FOR RESIDUE MES V 303 source : BC4 23) chain V residue 1 type catalytic sequence T description 177 source MCSA : MCSA2 24) chain V residue 17 type catalytic sequence D description 177 source MCSA : MCSA2 25) chain V residue 19 type catalytic sequence R description 177 source MCSA : MCSA2 26) chain V residue 33 type catalytic sequence K description 177 source MCSA : MCSA2 27) chain V residue 47 type catalytic sequence G description 177 source MCSA : MCSA2 28) chain V residue 129 type catalytic sequence S description 177 source MCSA : MCSA2 29) chain V residue 166 type catalytic sequence D description 177 source MCSA : MCSA2 30) chain V residue 169 type catalytic sequence S description 177 source MCSA : MCSA2

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