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eF-site ID
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4qz0-L |
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PDB Code
|
4qz0 |
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Chain
|
L |
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click to enlarge
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Title
|
yCP beta5-M45V mutant in complex with the epoxyketone inhibitor ONX 0914 |
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Classification
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HYDROLASE/HYDROLASE INHIBITOR |
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Compound
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Proteasome subunit alpha type-2 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
|
L: |
QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE
PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN
DKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKG
AVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQY
EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD
GLEILIVTKDGVRKEFYELKRD
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Description
|
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Functional site
|
|
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1)
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chain |
L |
| residue |
126 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE 04C K 301
|
| source |
: AC5
|
|
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2)
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chain |
L |
| residue |
222 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE MG V 302
|
| source |
: BC3
|
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3)
|
chain |
L |
| residue |
33 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE MES V 303
|
| source |
: BC4
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|
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4)
|
chain |
L |
| residue |
13-60 |
| type |
prosite |
| sequence |
LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM
SANGFAAD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFrFqgGIIVAVDsratagnwvasqtvk.KvieinpfllgtvaGgaAD
|
| source |
prosite : PS00854
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