eF-site ID 4qxp-AB PDB Code 4qxp Chain A, B click to enlarge Title Crystal structure of hSTING(G230I) in complex with DMXAA Classification IMMUNE SYSTEM Compound Stimulator of interferon genes protein Source null (STING_HUMAN) Sequence A:  SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGA VSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTIDRA GIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQ YSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIA YQEPADDSSFSLSQEVLRHLRQ B:  SVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGA VSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTIDRA GIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQ YSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIA YQEPADDSSFSLSQEVLRHLRQ Description Functional site 1) chain A residue 162 type sequence S description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 2) chain A residue 163 type sequence Y description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 3) chain A residue 167 type sequence Y description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 4) chain A residue 263 type sequence T description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 5) chain A residue 264 type sequence P description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 6) chain A residue 267 type sequence T description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 7) chain B residue 162 type sequence S description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 8) chain B residue 166 type sequence G description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 9) chain B residue 238 type sequence R description BINDING SITE FOR RESIDUE 1YE A 401 source : AC1 10) chain A residue 162 type sequence S description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 11) chain A residue 166 type sequence G description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 12) chain A residue 238 type sequence R description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 13) chain B residue 162 type sequence S description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 14) chain B residue 167 type sequence Y description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 15) chain B residue 263 type sequence T description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 16) chain B residue 264 type sequence P description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 17) chain B residue 267 type sequence T description BINDING SITE FOR RESIDUE 1YE B 401 source : AC2 18) chain A residue 263 type BINDING sequence T description BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G source Swiss-Prot : SWS_FT_FI4 19) chain B residue 263 type BINDING sequence T description BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G source Swiss-Prot : SWS_FT_FI4 20) chain A residue 236 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 source Swiss-Prot : SWS_FT_FI7 21) chain B residue 236 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:31968013 source Swiss-Prot : SWS_FT_FI7 22) chain A residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX source Swiss-Prot : SWS_FT_FI3 23) chain B residue 238 type BINDING sequence R description BINDING => ECO:0000269|PubMed:37379839, ECO:0007744|PDB:8GJX source Swiss-Prot : SWS_FT_FI3 24) chain A residue 229 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI5 25) chain B residue 229 type MOD_RES sequence T description Phosphothreonine => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI5 26) chain A residue 241 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI6 27) chain B residue 241 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:37832545 source Swiss-Prot : SWS_FT_FI6 28) chain A residue 162 type BINDING sequence S description BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y source Swiss-Prot : SWS_FT_FI1 29) chain B residue 162 type BINDING sequence S description BINDING => ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4F5Y source Swiss-Prot : SWS_FT_FI1 30) chain A residue 167 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G source Swiss-Prot : SWS_FT_FI2 31) chain B residue 167 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:22579474, ECO:0000269|PubMed:22705373, ECO:0000269|PubMed:22728658, ECO:0000269|PubMed:22728659, ECO:0000269|PubMed:22728660, ECO:0007744|PDB:4EF4, ECO:0007744|PDB:4EMT, ECO:0007744|PDB:4F5D, ECO:0007744|PDB:4F5Y, ECO:0007744|PDB:4F9G source Swiss-Prot : SWS_FT_FI2

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