eF-site ID 4qwx-K PDB Code 4qwx Chain K click to enlarge Title yCP in complex with the epoxyketone inhibitor ONX 0914 Classification HYDROLASE/HYDROLASE INHIBITOR Compound PROTEASOME SUBUNIT ALPHA TYPE-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence K:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain K residue 1 type sequence T description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 2) chain K residue 19 type sequence R description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 3) chain K residue 20 type sequence A description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 4) chain K residue 21 type sequence T description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 5) chain K residue 31 type sequence V description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 6) chain K residue 33 type sequence K description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 7) chain K residue 47 type sequence G description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 8) chain K residue 48 type sequence G description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 9) chain K residue 49 type sequence A description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 10) chain K residue 170 type sequence Y description BINDING SITE FOR RESIDUE 04C K 301 source : AC6 11) chain K residue 165 type sequence A description BINDING SITE FOR RESIDUE MG K 302 source : AC7 12) chain K residue 166 type sequence H description BINDING SITE FOR RESIDUE MG K 302 source : AC7 13) chain K residue 168 type sequence D description BINDING SITE FOR RESIDUE MG K 302 source : AC7 14) chain K residue 169 type sequence A description BINDING SITE FOR RESIDUE MG K 302 source : AC7 15) chain K residue 171 type sequence S description BINDING SITE FOR RESIDUE MG K 302 source : AC7 16) chain K residue 21 type sequence T description BINDING SITE FOR RESIDUE NA K 303 source : AC8 17) chain K residue 1 type sequence T description BINDING SITE FOR RESIDUE MES K 304 source : AC9 18) chain K residue 47 type sequence G description BINDING SITE FOR RESIDUE MES K 304 source : AC9 19) chain K residue 96 type sequence S description BINDING SITE FOR RESIDUE MES K 304 source : AC9 20) chain K residue 97 type sequence M description BINDING SITE FOR RESIDUE MES K 304 source : AC9 21) chain K residue 130 type sequence G description BINDING SITE FOR RESIDUE MES K 304 source : AC9 22) chain K residue 131 type sequence S description BINDING SITE FOR RESIDUE MES K 304 source : AC9 23) chain K residue 49 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI2 24) chain K residue 4-51 type prosite sequence LAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLG TMAGGAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. ISMkYdnGVIIAADnlgsygsllrfngve.RlipvgdntvvgisGdiSD source prosite : PS00854

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