eF-site ID 4qwu-V PDB Code 4qwu Chain V click to enlarge Title yCP beta5-C52F mutant in complex with bortezomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence V:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICDIQEE Description Functional site 1) chain V residue 69 type sequence Y description BINDING SITE FOR RESIDUE CL U 301 source : BC1 2) chain V residue 1 type sequence T description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 3) chain V residue 20 type sequence S description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 4) chain V residue 21 type sequence T description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 5) chain V residue 45 type sequence G description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 6) chain V residue 47 type sequence G description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 7) chain V residue 48 type sequence T description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 8) chain V residue 49 type sequence A description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 9) chain V residue 52 type sequence T description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 10) chain V residue 168 type sequence G description BINDING SITE FOR RESIDUE BO2 V 301 source : BC2 11) chain V residue 19 type sequence R description BINDING SITE FOR RESIDUE MG V 302 source : BC3 12) chain V residue 163 type sequence I description BINDING SITE FOR RESIDUE MG V 302 source : BC3 13) chain V residue 166 type sequence D description BINDING SITE FOR RESIDUE MG V 302 source : BC3 14) chain V residue 169 type sequence S description BINDING SITE FOR RESIDUE MG V 302 source : BC3 15) chain V residue 114 type sequence H description BINDING SITE FOR RESIDUE BO2 b 201 source : BC7 16) chain V residue 118 type sequence S description BINDING SITE FOR RESIDUE BO2 b 201 source : BC7 17) chain V residue 1 type catalytic sequence T description 177 source MCSA : MCSA2 18) chain V residue 17 type catalytic sequence D description 177 source MCSA : MCSA2 19) chain V residue 19 type catalytic sequence R description 177 source MCSA : MCSA2 20) chain V residue 33 type catalytic sequence K description 177 source MCSA : MCSA2 21) chain V residue 47 type catalytic sequence G description 177 source MCSA : MCSA2 22) chain V residue 129 type catalytic sequence S description 177 source MCSA : MCSA2 23) chain V residue 166 type catalytic sequence D description 177 source MCSA : MCSA2 24) chain V residue 169 type catalytic sequence S description 177 source MCSA : MCSA2

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