eF-site ID 4qwl-b PDB Code 4qwl Chain b click to enlarge Title yCP beta5-A50V mutant in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence b:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL Description Functional site 1) chain b residue 1 type sequence T description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 2) chain b residue 20 type sequence T description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 3) chain b residue 21 type sequence T description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 4) chain b residue 22 type sequence T description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 5) chain b residue 45 type sequence R description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 6) chain b residue 46 type sequence S description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 7) chain b residue 47 type sequence G description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 8) chain b residue 49 type sequence A description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 9) chain b residue 129 type sequence S description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 10) chain b residue 168 type sequence S description BINDING SITE FOR RESIDUE 3BV b 201 source : CC1 11) chain b residue 31 type sequence T description BINDING SITE FOR RESIDUE CL b 202 source : CC2 12) chain b residue 45 type sequence R description BINDING SITE FOR RESIDUE CL b 202 source : CC2 13) chain b residue 53 type sequence Q description BINDING SITE FOR RESIDUE CL b 202 source : CC2 14) chain b residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1 15) chain b residue 4-51 type prosite sequence MAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDKIWC CRSGSAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD source prosite : PS00854

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