eF-site ID 4qwl-L PDB Code 4qwl Chain L click to enlarge Title yCP beta5-A50V mutant in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence L:  QFNPYGDNGGTILGIAGEDFAVLAGDTRNITDYSINSRYE PKVFDCGDNIVMSANGFAADGDALVKRFKNSVKWYHFDHN DKKLSINSAARNIQHLLYGKRFFPYYVHTIIAGLDEDGKG AVYSFDPVGSYEREQCRAGGAAASLIMPFLDNQVNFKNQY EPGTNGKVKKPLKYLSVEEVIKLVRDSFTSATERHIQVGD GLEILIVTKDGVRKEFYELKRD Description Functional site 1) chain L residue 101 type sequence R description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 2) chain L residue 108 type sequence H description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 3) chain L residue 126 type sequence D description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 4) chain L residue 127 type sequence P description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 5) chain L residue 130 type sequence S description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 6) chain L residue 222 type sequence D description BINDING SITE FOR RESIDUE MG V 302 source : BC5 7) chain L residue 13-60 type prosite sequence LGIAGEDFAVLAGDTRNITDYSINSRYEPKVFDCGDNIVM SANGFAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIaGedFAVLAGDtrnitdysinsryep.KvfdcgdnivmsanGfaAD source prosite : PS00854

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