eF-site ID 4qwl-N PDB Code 4qwl Chain N click to enlarge Title yCP beta5-A50V mutant in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence N:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL Description Functional site 1) chain N residue 1 type sequence T description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 2) chain N residue 20 type sequence T description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 3) chain N residue 21 type sequence T description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 4) chain N residue 22 type sequence T description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 5) chain N residue 45 type sequence R description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 6) chain N residue 46 type sequence S description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 7) chain N residue 47 type sequence G description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 8) chain N residue 49 type sequence A description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 9) chain N residue 129 type sequence S description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 10) chain N residue 168 type sequence S description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 11) chain N residue 19 type sequence R description BINDING SITE FOR RESIDUE MG N 202 source : AC9 12) chain N residue 163 type sequence I description BINDING SITE FOR RESIDUE MG N 202 source : AC9 13) chain N residue 166 type sequence D description BINDING SITE FOR RESIDUE MG N 202 source : AC9 14) chain N residue 169 type sequence S description BINDING SITE FOR RESIDUE MG N 202 source : AC9 15) chain N residue 51 type sequence D description BINDING SITE FOR RESIDUE MG N 203 source : BC1 16) chain N residue 92 type sequence N description BINDING SITE FOR RESIDUE MG N 203 source : BC1 17) chain N residue 31 type sequence T description BINDING SITE FOR RESIDUE CL N 204 source : BC2 18) chain N residue 45 type sequence R description BINDING SITE FOR RESIDUE CL N 204 source : BC2 19) chain N residue 53 type sequence Q description BINDING SITE FOR RESIDUE CL N 204 source : BC2 20) chain N residue 1 type ACT_SITE sequence T description Nucleophile => ECO:0000269|PubMed:9087403 source Swiss-Prot : SWS_FT_FI1

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