eF-site ID 4qwg-Y PDB Code 4qwg Chain Y click to enlarge Title yCP beta5-A49V mutant in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence Y:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGVADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain Y residue 1 type sequence T description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 2) chain Y residue 19 type sequence R description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 3) chain Y residue 20 type sequence A description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 4) chain Y residue 21 type sequence T description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 5) chain Y residue 22 type sequence A description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 6) chain Y residue 33 type sequence K description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 7) chain Y residue 47 type sequence G description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 8) chain Y residue 49 type sequence V description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 9) chain Y residue 170 type sequence Y description BINDING SITE FOR RESIDUE 3BV Y 301 source : BC5 10) chain Y residue 165 type sequence A description BINDING SITE FOR RESIDUE MG Y 302 source : BC6 11) chain Y residue 168 type sequence D description BINDING SITE FOR RESIDUE MG Y 302 source : BC6 12) chain Y residue 171 type sequence S description BINDING SITE FOR RESIDUE MG Y 302 source : BC6 13) chain Y residue 1 type sequence T description BINDING SITE FOR RESIDUE MES Y 303 source : BC7 14) chain Y residue 47 type sequence G description BINDING SITE FOR RESIDUE MES Y 303 source : BC7 15) chain Y residue 97 type sequence M description BINDING SITE FOR RESIDUE MES Y 303 source : BC7 16) chain Y residue 117 type sequence S description BINDING SITE FOR RESIDUE MES Y 303 source : BC7 17) chain Y residue 130 type sequence G description BINDING SITE FOR RESIDUE MES Y 303 source : BC7 18) chain Y residue 131 type sequence S description BINDING SITE FOR RESIDUE MES Y 303 source : BC7 19) chain Y residue 49 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2

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