eF-site ID 4qwg-K PDB Code 4qwg Chain K click to enlarge Title yCP beta5-A49V mutant in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence K:  TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF LLGTMAGGVADCQFWETWLGSQCRLHELREKERISVAAAS KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV KEEEGSFNNVIG Description Functional site 1) chain K residue 1 type sequence T description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 2) chain K residue 19 type sequence R description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 3) chain K residue 20 type sequence A description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 4) chain K residue 21 type sequence T description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 5) chain K residue 22 type sequence A description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 6) chain K residue 33 type sequence K description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 7) chain K residue 47 type sequence G description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 8) chain K residue 49 type sequence V description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 9) chain K residue 170 type sequence Y description BINDING SITE FOR RESIDUE 3BV K 301 source : AC5 10) chain K residue 165 type sequence A description BINDING SITE FOR RESIDUE MG K 302 source : AC6 11) chain K residue 168 type sequence D description BINDING SITE FOR RESIDUE MG K 302 source : AC6 12) chain K residue 171 type sequence S description BINDING SITE FOR RESIDUE MG K 302 source : AC6 13) chain K residue 1 type sequence T description BINDING SITE FOR RESIDUE MES K 303 source : AC7 14) chain K residue 47 type sequence G description BINDING SITE FOR RESIDUE MES K 303 source : AC7 15) chain K residue 97 type sequence M description BINDING SITE FOR RESIDUE MES K 303 source : AC7 16) chain K residue 117 type sequence S description BINDING SITE FOR RESIDUE MES K 303 source : AC7 17) chain K residue 130 type sequence G description BINDING SITE FOR RESIDUE MES K 303 source : AC7 18) chain K residue 131 type sequence S description BINDING SITE FOR RESIDUE MES K 303 source : AC7 19) chain K residue 49 type BINDING sequence V description source Swiss-Prot : SWS_FT_FI2 20) chain K residue 4-51 type prosite sequence LAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLG TMAGGVAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIaGedFAVLAGDtrnitdysinsryep.KvfdcgdnivmsanGfaAD source prosite : PS00854

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