eF-site ID 4qw5-H PDB Code 4qw5 Chain H click to enlarge Title yCP beta5-M45A mutant in complex with carfilzomib Classification HYDROLASE/HYDROLASE INHIBITOR Compound Proteasome subunit alpha type-2 Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; Sequence H:  TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ KSYKFPRGTTAVLKESIVNICD Description Functional site 1) chain H residue 69 type sequence Y description BINDING SITE FOR RESIDUE CL G 302 source : AC2 2) chain H residue 1 type sequence T description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 3) chain H residue 19 type sequence R description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 4) chain H residue 20 type sequence S description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 5) chain H residue 21 type sequence T description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 6) chain H residue 27 type sequence A description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 7) chain H residue 33 type sequence K description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 8) chain H residue 45 type sequence G description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 9) chain H residue 47 type sequence G description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 10) chain H residue 48 type sequence T description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 11) chain H residue 49 type sequence A description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 12) chain H residue 168 type sequence G description BINDING SITE FOR RESIDUE 3BV H 301 source : AC3 13) chain H residue 47 type sequence G description BINDING SITE FOR RESIDUE MES H 302 source : AC4 14) chain H residue 129 type sequence S description BINDING SITE FOR RESIDUE MES H 302 source : AC4 15) chain H residue 114 type sequence H description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 16) chain H residue 116 type sequence H description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 17) chain H residue 118 type sequence S description BINDING SITE FOR RESIDUE 3BV N 201 source : AC8 18) chain H residue 4-51 type prosite sequence VGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPKIWC AGAGTAAD description PROTEASOME_BETA_1 Proteasome beta-type subunits signature. LAFrFqgGIIVAVDsratagnwvasqtvk.KvieinpfllgtaaGgaAD source prosite : PS00854 19) chain H residue 1 type catalytic sequence T description 177 source MCSA : MCSA1 20) chain H residue 17 type catalytic sequence D description 177 source MCSA : MCSA1 21) chain H residue 19 type catalytic sequence R description 177 source MCSA : MCSA1 22) chain H residue 33 type catalytic sequence K description 177 source MCSA : MCSA1 23) chain H residue 47 type catalytic sequence G description 177 source MCSA : MCSA1 24) chain H residue 129 type catalytic sequence S description 177 source MCSA : MCSA1 25) chain H residue 166 type catalytic sequence D description 177 source MCSA : MCSA1 26) chain H residue 169 type catalytic sequence S description 177 source MCSA : MCSA1

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