eF-site ID 4qvn-N
PDB Code 4qvn
Chain N

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Title yCP beta5-M45V mutant in complex with bortezomib
Classification HYDROLASE/HYDROLASE INHIBITOR
Compound Proteasome subunit alpha type-2
Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae;
Sequence N:  TSIMAVTFKDGVILGADSRTTTGAYIANRVTDKLTRVHDK
IWCCRSGSAADTQAIADIVQYHLELYTSQYGTPSTETAAS
VFKELCYENKDNLTAGIIVAGYDDKNKGEVYTIPLGGSVH
KLPYAIAGSGSTFIYGYCDKNFRENMSKEETVDFIKHSLS
QAIKWDGSSGGVIRMVVLTAAGVERLIFYPDEYEQL
Description


Functional site

1) chain N
residue 1
type
sequence T
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

2) chain N
residue 20
type
sequence T
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

3) chain N
residue 21
type
sequence T
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

4) chain N
residue 22
type
sequence T
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

5) chain N
residue 45
type
sequence R
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

6) chain N
residue 47
type
sequence G
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

7) chain N
residue 49
type
sequence A
description BINDING SITE FOR RESIDUE BO2 N 201
source : AC9

8) chain N
residue 19
type
sequence R
description BINDING SITE FOR RESIDUE MG N 202
source : BC1

9) chain N
residue 163
type
sequence I
description BINDING SITE FOR RESIDUE MG N 202
source : BC1

10) chain N
residue 166
type
sequence D
description BINDING SITE FOR RESIDUE MG N 202
source : BC1

11) chain N
residue 169
type
sequence S
description BINDING SITE FOR RESIDUE MG N 202
source : BC1

12) chain N
residue 31
type
sequence T
description BINDING SITE FOR RESIDUE CL N 203
source : BC2

13) chain N
residue 45
type
sequence R
description BINDING SITE FOR RESIDUE CL N 203
source : BC2

14) chain N
residue 53
type
sequence Q
description BINDING SITE FOR RESIDUE CL N 203
source : BC2

15) chain N
residue 1
type ACT_SITE
sequence T
description Nucleophile => ECO:0000269|PubMed:9087403
source Swiss-Prot : SWS_FT_FI1


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