eF-site ID 4qr9-A PDB Code 4qr9 Chain A click to enlarge Title Crystal structure of two HMGB1 Box A domains cooperating to underwind and kink a DNA Classification DNA BINDING PROTEIN Compound High mobility group protein B1 Source Rattus norvegicus (Rat) (4QR9) Sequence A:  GSKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKC SERWKTMSAKEKGKFEDMAKADKARYEREMKTYIP Description Functional site 1) chain A residue 27 type CROSSLNK sequence K description Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000250|UniProtKB:P09429 source Swiss-Prot : SWS_FT_FI8 2) chain A residue 42 type CROSSLNK sequence K description Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000250|UniProtKB:P09429 source Swiss-Prot : SWS_FT_FI8 3) chain A residue 43 type CROSSLNK sequence K description Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000250|UniProtKB:P09429 source Swiss-Prot : SWS_FT_FI8 4) chain A residue 67 type CROSSLNK sequence K description Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-?) => ECO:0000250|UniProtKB:P09429 source Swiss-Prot : SWS_FT_FI8 5) chain A residue 8-78 type DNA_BIND sequence PRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSER WKTMSAKEKGKFEDMAKADKARYEREMKTYI description HMG box 1 => ECO:0000255|PROSITE-ProRule:PRU00267 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 9 type SITE sequence R description Cleavage; by thrombin:thrombomodulin => ECO:0000250|UniProtKB:P10103 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 66 type SITE sequence D description Cleavage; by CASP1 => ECO:0000250|UniProtKB:P09429 source Swiss-Prot : SWS_FT_FI3 8) chain A residue 7 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P10103 source Swiss-Prot : SWS_FT_FI4 9) chain A residue 11 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P10103 source Swiss-Prot : SWS_FT_FI4 10) chain A residue 27 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P10103 source Swiss-Prot : SWS_FT_FI4 11) chain A residue 28 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P10103 source Swiss-Prot : SWS_FT_FI4 12) chain A residue 29 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P10103 source Swiss-Prot : SWS_FT_FI4 13) chain A residue 40-51 type prosite sequence FSKKCSERWKTM description HMG_BOX_1 HMG box A DNA-binding domain signature. FSKKCsERWKTM source prosite : PS00353 14) chain A residue 22 type MOD_RES sequence C description Cysteine sulfonic acid (-SO3H); alternate => ECO:0000305|PubMed:22869893 source Swiss-Prot : SWS_FT_FI5 15) chain A residue 44 type MOD_RES sequence C description Cysteine sulfonic acid (-SO3H); alternate => ECO:0000305|PubMed:22869893 source Swiss-Prot : SWS_FT_FI5 16) chain A residue 34 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P09429 source Swiss-Prot : SWS_FT_FI6 17) chain A residue 42 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P63158 source Swiss-Prot : SWS_FT_FI7

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