eF-site ID 4qqz-A PDB Code 4qqz Chain A click to enlarge Title Crystal structure of T. fusca Cas3-AMPPNP Classification Hydrolase/DNA Compound CRISPR-associated helicase, Cas3 family Source Thermobifida fusca (strain YX) (4QQZ) Sequence A:  PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYL SPGLRDTIASSMETDEEHAGHCIAFWAGLHDIGKLTREFQ QQIAIDLSAYPGEELSGEQRSHAAATGKWLPFALPSLGYP NGGLVTGLVAQMLGGHHGTFHPHPSFQSRNPLAEFGFSSP HWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPS LLDAAGLRPITVPPATFTESFPHLSKPNGLQASLAKHLPC LCTGPGLVLITAPMGEGKTEAAYHVADLLGKATGRPGRFL ALPTMATADQMHTRLKEYARYRVEPRSSTLALLHSMAWLN PDYAPALGHRDPFAATDWLMGRKRGLLAPWAVGTIDQALM AVLRAKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLL RWLGTLDVPVVLLSATLHHSIANSLVKAYLEGARGRRWNR SEPQPVSEVSYPGWLHVDARIGKVTRSSDVDPLPIATTPR KPLEVRLVDVPVKEGALNRSTVLAKELTPLVKQGGCAAII CTTVAEAQGVYDLLSQWFATLAPDLYLLHSRFPNRQRTEI TATIVDLFGKEGAQSGRRPTAVLVATQVVEQSLDLDVDLM ISDLAPVSLLLQRAGRCWRHEHLGIINRPQWAKQPELVVL TPEQNRAPWFPRSWTSVYPLALLQRTYTLLRRRNGAPVQI PEDVQQLVDDVYDDDSLAEDLEADMERMGEELAQRGLARN AVIPDPDDAEDNLNGLTEFSFHVLATRFGAGSVRVLCYYV DTAGNRWLDPECTVEFPEQGTGREGRFTMADCRDLVARTI PVRMGPWASQLTEDNHPPEAWRESFYLRDLVLIPQRVTDE GAVLPTETGGREWLLDPCKGLIF Description Functional site 1) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 2) chain A residue 115 type sequence H description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 3) chain A residue 149 type sequence H description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 4) chain A residue 150 type sequence H description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 5) chain A residue 37 type sequence H description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 6) chain A residue 83 type sequence H description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 7) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 8) chain A residue 215 type sequence D description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 9) chain A residue 277 type sequence L description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 10) chain A residue 279 type sequence K description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 11) chain A residue 284 type sequence Q description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 12) chain A residue 308 type sequence G description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 13) chain A residue 309 type sequence E description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 14) chain A residue 310 type sequence G description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 15) chain A residue 312 type sequence T description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 16) chain A residue 313 type sequence E description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3 17) chain A residue 692 type sequence R description BINDING SITE FOR RESIDUE ANP A 1003 source : AC3

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