eF-site ID 4qqy-ACEG PDB Code 4qqy Chain A, C, E, G Title Crystal structure of T. fusca Cas3-ADP Classification Hydrolase/DNA Compound CRISPR-associated helicase, Cas3 family Source Thermobifida fusca (strain YX) (4QQY) Sequence A:  PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYL SPGLRDTIASSMETDEEHAGHCIAFWAGLHDIGKLTREFQ QQIAIDLSAYPGEELSGEQRSHAAATGKWLPFALPSLGYP NGGLVTGLVAQMLGGHHGTFHPHPSFQSRNPLAEFGFSSP HWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPS LLDAAGLRPITVPPATFTESFPHLSKPNGLQASLAKHLPC LCTGPGLVLITAPMGEGKTEAAYHVADLLGKATGRPGRFL ALPTMATADQMHTRLKEYARYRVEPRSSTLALLHSMAWLN PDYAPAGHRDPFAATDWLMGRKRGLLAPWAVGTIDQALMA VLRAKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLR WLGTLDVPVVLLSATLHHSIANSLVKAYLEGARGRRWNRS EPQPVSEVSYPGWLHVDARIGKVTRSSDVDPLPIATTPRK PLEVRLVDVPVKEGALNRSTVLAKELTPLVKQGGCAAIIC TTVAEAQGVYDLLSQWFATAPDLYLLHSRFPNRQRTEITA TIVDLFGKEGAQSGRRPTAVLVATQVVEQSLDLDVDLMIS DLAPVSLLLQRAGRCWRHEHLGIINRPQWAKQPELVVLTP EQNRAPWFPRSWTSVYPLALLQRTYTLLRRRNGAPVQIPE DVQQLVDDVYDDDSLAEDLEADMERMGEELAQRGLARNAV IPDPDDAEDNLNGLTEFSFHVLATRFGAGSVRVLCYYVDT AGNRWLDPECTVEFPEQGTEGRFTMADCRDLVARTIPVRM GPWASQLTEDNHPPEAWRESFYLRDLVLIPQRVTDVLPTE TGGREWLLDPCKGLIF C:  PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYL SPGLRDTIASSMETDEEHAGHCIAFWAGLHDIGKLTREFQ QQIAIDLSAYPGEELSGEQRSHAAATGKWLPFALPSLGYP NGGLVTGLVAQMLGGHHGTFHPHPSFQSRNPLAEFGFSSP HWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPS LLDAAGLRPITVPPATFTESFPHLSKPNGLQASLAKHLPC LCTGPGLVLITAPMGEGKTEAAYHVADLLGKATGRPGRFL ALPTMATADQMHTRLKEYARYRVENTRSSTLALLHSMAWL NPDYAPADPFAATDWLMGRKRGLLAPWAVGTIDQALMAVL RAKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWL GTLDVPVVLLSATLHHSIANSLVKAYLEGARGRRWNRSEP QPVSEVSYPGWLHVDARIGKVTRSSDVDPLPIATTPRKPL EVRLVDVPVKEGALNRSTVLAKELTPLVKQGGCAAIICTT VAEAQGVYDLLSQWFATLGEDAPDLYLLHSRFPNRQRTEI TATIVDLFGKEGAQSGRRPTRGAVLVATQVVEQSLDLDVD LMISDLAPVSLLLQRAGRCWRHEHLGIINRPQWAKQPELV VLTPEQNAPWFPRSWTSVYPLALLQRTYTLLRRRNGAPVQ IPEDVQQLVDDVYDDDSLAEDLEADMERMGEELAQRGLAR NAVIPDPDDAEDNLNGLTEFSVLATRFGAGSVRVLCYYVD TAGNRWLDPECTVEFPEQGTGREGRFTMADCRDLVARTIP VRMGPWASQLTEDNHPPEAWRESFYLRDLVLIPQRVTDEG AVLPTETGGREWLLDPCKGLIF E:  PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYL SPGLRDTIASSMETDEEHAGHCIAFWAGLHDIGKLTREFQ QQIAIDLSAYPGEELSGEQRSHAAATGKWLPFALPSLGYP NGGLVTGLVAQMLGGHHGTFHPHPSFQSRNPLAEFGFSSP HWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPS LLDAAGLRPITVPPATFTESFPHLSKPNGLQASLAKHLPC LCTGPGLVLITAPMGEGKTEAAYHVADLLGKATGRPGRFL ALPTMATADQMHTRLKEYARYRVENTRSSTLALLHSMAWL NPDYAPADPFAATDWLMGRKRGLLAPWAVGTIDQALMAVL RAKHNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWL GTLDVPVVLLSATLHHSIANSLVKAYLEGARGRRWNRSEP QPVSEVSYPGWLHVDARIGKVTRSSDVDPLPIATTPRKPL EVRLVDVPVKEGALNRSTVLAKELTPLVKQGGCAAIICTT VAEAQGVYDLLSQWFATLGEDAPDLYLLHSRFPNRQRTEI TATIVDLFGKEGAQSGRRPTRGAVLVATQVVEQSLDLDVD LMISDLAPVSLLLQRAGRCWRHEHLGIINRPQWAKQPELV VLTPEQNRAPWFPRSWTSVYPLALLQRTYTLLRRRNGAPV QIPEDVQQLVDDVYDDDSLAEDLEADMERMGEELAQRGLA RNAVIPDPDDAEDNLNGLTEFVLATRFGAGSVRVLCYYVD TAGNRWLDPECTVEFPEQGTGREGRFTMADCRDLVARTIP VRMGPWASQLTEDNHPPEAWRESFYLRDLVLIPQRVTDEG AVLPTETGGREWLLDPCKGLIF G:  PPLDLRFWAKERGLRGKTYPLVCHSLDAAAAALVLWNEYL SPGLRDTIASSMETDEEHAGHCIAFWAGLHDIGKLTREFQ QQIAIDLSAYPGEELSGEQRSHAAATGKWLPFALPSLGYP NGGLVTGLVAQMLGGHHGTFHPHPSFQSRNPLAEFGFSSP HWEKQRHALLHAVFDATGRPTPPDMLDGPTASVVCGLVIL ADWLVSQEDFLLERLTSLPADGSASALRAHFETSLRRIPS LLDAAGLRPITVPPATFTESFPHLSKPNGLQASLAKHLPC LCTGPGLVLITAPMGEGKTEAAYHVADLLGKATGRPGRFL ALPTMATADQMHTRLKEYARYRVENSSTLALLHSMAWLNP DYAPAPFAATDWLMGRKRGLLAPWAVGTIDQALMAVLRAK HNALRLFGLAGKVVVVDEAHAVDPYMQVLLEQLLRWLGTL DVPVVLLSATLHHSIANSLVKAYLEGARGRRWNRSEPQPV SEVSYPGWLHVDARIGKVTRSSDVDPLPIATTPRKPLEVR LVDVPVKEGALNRSTVLAKELTPLVKQGGCAAIICTTVAE AQGVYDLLSQWFATAPDLYLLHSRFPNRQRTEITATIVDL FGKEGAQSGRRPTRGAVLVATQVVEQSLDLDVDLMISDLA PVSLLLQRAGRCWRHEHLGIINRPQWAKQPELVVLTPEQN RAPWFPRSWTSVYPLALLQRTYTLLRRRNGAPVQIPEDVQ QLVDDVYDDDSLAEDLEADMERMGEELAQRGLARNAVIPD PDDAEDNLNGLTEFSVLATRFGAGSVRVLCYYVAGNRWLD PECTVEFPEQGTGREGRFTMADCRDLVARTIPVRMGPWAS QLTEDNHPPEAWRESFYLRDLVLIPQRVTDEGAVLPTETG GREWLLDPCKGLIF Description Functional site 1) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 2) chain A residue 115 type sequence H description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 3) chain A residue 149 type sequence H description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 4) chain A residue 150 type sequence H description BINDING SITE FOR RESIDUE FE A 1001 source : AC1 5) chain A residue 37 type sequence H description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 6) chain A residue 83 type sequence H description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 7) chain A residue 84 type sequence D description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 8) chain A residue 215 type sequence D description BINDING SITE FOR RESIDUE FE A 1002 source : AC2 9) chain A residue 277 type sequence L description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 10) chain A residue 279 type sequence K description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 11) chain A residue 280 type sequence P description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 12) chain A residue 281 type sequence N description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 13) chain A residue 284 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 14) chain A residue 307 type sequence M description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 15) chain A residue 308 type sequence G description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 16) chain A residue 309 type sequence E description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 17) chain A residue 310 type sequence G description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 18) chain A residue 313 type sequence E description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 19) chain A residue 692 type sequence R description BINDING SITE FOR RESIDUE ADP A 1003 source : AC3 20) chain C residue 84 type sequence D description BINDING SITE FOR RESIDUE FE C 1001 source : AC4 21) chain C residue 115 type sequence H description BINDING SITE FOR RESIDUE FE C 1001 source : AC4 22) chain C residue 149 type sequence H description BINDING SITE FOR RESIDUE FE C 1001 source : AC4 23) chain C residue 150 type sequence H description BINDING SITE FOR RESIDUE FE C 1001 source : AC4 24) chain C residue 37 type sequence H description BINDING SITE FOR RESIDUE FE C 1002 source : AC5 25) chain C residue 83 type sequence H description BINDING SITE FOR RESIDUE FE C 1002 source : AC5 26) chain C residue 84 type sequence D description BINDING SITE FOR RESIDUE FE C 1002 source : AC5 27) chain C residue 215 type sequence D description BINDING SITE FOR RESIDUE FE C 1002 source : AC5 28) chain C residue 277 type sequence L description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 29) chain C residue 279 type sequence K description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 30) chain C residue 281 type sequence N description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 31) chain C residue 284 type sequence Q description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 32) chain C residue 307 type sequence M description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 33) chain C residue 308 type sequence G description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 34) chain C residue 309 type sequence E description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 35) chain C residue 310 type sequence G description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 36) chain C residue 313 type sequence E description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 37) chain C residue 692 type sequence R description BINDING SITE FOR RESIDUE ADP C 1003 source : AC6 38) chain E residue 84 type sequence D description BINDING SITE FOR RESIDUE FE E 1001 source : AC7 39) chain E residue 115 type sequence H description BINDING SITE FOR RESIDUE FE E 1001 source : AC7 40) chain E residue 149 type sequence H description BINDING SITE FOR RESIDUE FE E 1001 source : AC7 41) chain E residue 150 type sequence H description BINDING SITE FOR RESIDUE FE E 1001 source : AC7 42) chain E residue 37 type sequence H description BINDING SITE FOR RESIDUE FE E 1002 source : AC8 43) chain E residue 83 type sequence H description BINDING SITE FOR RESIDUE FE E 1002 source : AC8 44) chain E residue 84 type sequence D description BINDING SITE FOR RESIDUE FE E 1002 source : AC8 45) chain E residue 215 type sequence D description BINDING SITE FOR RESIDUE FE E 1002 source : AC8 46) chain E residue 277 type sequence L description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 47) chain E residue 278 type sequence S description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 48) chain E residue 279 type sequence K description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 49) chain E residue 280 type sequence P description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 50) chain E residue 281 type sequence N description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 51) chain E residue 284 type sequence Q description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 52) chain E residue 308 type sequence G description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 53) chain E residue 310 type sequence G description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 54) chain E residue 312 type sequence T description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 55) chain E residue 313 type sequence E description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 56) chain E residue 347 type sequence R description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 57) chain E residue 692 type sequence R description BINDING SITE FOR RESIDUE ADP E 1003 source : AC9 58) chain G residue 84 type sequence D description BINDING SITE FOR RESIDUE FE G 1001 source : BC1 59) chain G residue 115 type sequence H description BINDING SITE FOR RESIDUE FE G 1001 source : BC1 60) chain G residue 149 type sequence H description BINDING SITE FOR RESIDUE FE G 1001 source : BC1 61) chain G residue 150 type sequence H description BINDING SITE FOR RESIDUE FE G 1001 source : BC1 62) chain G residue 37 type sequence H description BINDING SITE FOR RESIDUE FE G 1002 source : BC2 63) chain G residue 83 type sequence H description BINDING SITE FOR RESIDUE FE G 1002 source : BC2 64) chain G residue 84 type sequence D description BINDING SITE FOR RESIDUE FE G 1002 source : BC2 65) chain G residue 87 type sequence K description BINDING SITE FOR RESIDUE FE G 1002 source : BC2 66) chain G residue 215 type sequence D description BINDING SITE FOR RESIDUE FE G 1002 source : BC2 67) chain G residue 277 type sequence L description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 68) chain G residue 279 type sequence K description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 69) chain G residue 281 type sequence N description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 70) chain G residue 284 type sequence Q description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 71) chain G residue 307 type sequence M description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 72) chain G residue 308 type sequence G description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 73) chain G residue 309 type sequence E description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 74) chain G residue 310 type sequence G description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 75) chain G residue 313 type sequence E description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 76) chain G residue 347 type sequence R description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3 77) chain G residue 692 type sequence R description BINDING SITE FOR RESIDUE ADP G 1003 source : BC3

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