eF-site ID 4qqc-A
PDB Code 4qqc
Chain A

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Title Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations
Classification Transferase/transferase inhibitor
Compound Fibroblast growth factor receptor 4
Source Homo sapiens (Human) (FGFR4_HUMAN)
Sequence A:  DPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVV
RAEAFGMDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI
GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRP
PGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLV
TEDNVMKIADFGLLPVKWMAPEALFDEVYTHQSDVWSFGI
LLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPE
LYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV
Description


Functional site

1) chain A
residue 475
type
sequence E
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

2) chain A
residue 477
type
sequence C
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

3) chain A
residue 478
type
sequence F
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

4) chain A
residue 481
type
sequence V
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

5) chain A
residue 503
type
sequence K
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

6) chain A
residue 520
type
sequence E
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

7) chain A
residue 524
type
sequence M
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

8) chain A
residue 548
type
sequence V
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

9) chain A
residue 551
type
sequence E
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

10) chain A
residue 552
type
sequence C
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

11) chain A
residue 553
type
sequence A
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

12) chain A
residue 619
type
sequence L
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

13) chain A
residue 629
type
sequence A
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

14) chain A
residue 630
type
sequence D
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

15) chain A
residue 631
type
sequence F
description BINDING SITE FOR RESIDUE 37O A 801
source : AC1

16) chain A
residue 563
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 802
source : AC2

17) chain A
residue 566
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 802
source : AC2

18) chain A
residue 687
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 802
source : AC2

19) chain A
residue 688
type
sequence S
description BINDING SITE FOR RESIDUE SO4 A 802
source : AC2

20) chain A
residue 473-503
type prosite
sequence LGEGCFGQVVRAEAFGMDQASTVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVrAeafgmdparpdqast...VAVK
source prosite : PS00107

21) chain A
residue 608-620
type prosite
sequence CIHRDLAARNVLV
description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV
source prosite : PS00109

22) chain A
residue 612
type ACT_SITE
sequence D
description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028
source Swiss-Prot : SWS_FT_FI1

23) chain A
residue 473
type BINDING
sequence L
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2

24) chain A
residue 503
type BINDING
sequence K
description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159
source Swiss-Prot : SWS_FT_FI2


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