eF-site ID 4qqc-A PDB Code 4qqc Chain A click to enlarge Title Crystal Structure of FGF Receptor (FGFR) 4 Kinase Domain in Complex with FIIN-2, an Irreversible Tyrosine Kinase Inhibitor Capable of Overcoming FGFR Kinase Gate-Keeper Mutations Classification Transferase/transferase inhibitor Compound Fibroblast growth factor receptor 4 Source Homo sapiens (Human) (FGFR4_HUMAN) Sequence A:  DPLLAGLVSLDLPLDPLWEFPRDRLVLGKPLGEGCFGQVV RAEAFGMDQASTVAVKMLKDNASDKDLADLVSEMEVMKLI GRHKNIINLLGVCTQEGPLYVIVECAAKGNLREFLRARRP PGPLSFPVLVSCAYQVARGMQYLESRKCIHRDLAARNVLV TEDNVMKIADFGLLPVKWMAPEALFDEVYTHQSDVWSFGI LLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPPHCPPE LYGLMRECWHAAPSQRPTFKQLVEALDKVLLAV Description Functional site 1) chain A residue 475 type sequence E description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 2) chain A residue 477 type sequence C description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 3) chain A residue 478 type sequence F description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 4) chain A residue 481 type sequence V description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 5) chain A residue 503 type sequence K description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 6) chain A residue 520 type sequence E description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 7) chain A residue 524 type sequence M description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 8) chain A residue 548 type sequence V description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 9) chain A residue 551 type sequence E description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 10) chain A residue 552 type sequence C description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 11) chain A residue 553 type sequence A description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 12) chain A residue 619 type sequence L description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 13) chain A residue 629 type sequence A description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 14) chain A residue 630 type sequence D description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 15) chain A residue 631 type sequence F description BINDING SITE FOR RESIDUE 37O A 801 source : AC1 16) chain A residue 563 type sequence R description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 17) chain A residue 566 type sequence R description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 18) chain A residue 687 type sequence G description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 19) chain A residue 688 type sequence S description BINDING SITE FOR RESIDUE SO4 A 802 source : AC2 20) chain A residue 473-503 type prosite sequence LGEGCFGQVVRAEAFGMDQASTVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVrAeafgmdparpdqast...VAVK source prosite : PS00107 21) chain A residue 608-620 type prosite sequence CIHRDLAARNVLV description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV source prosite : PS00109 22) chain A residue 612 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 473 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain A residue 503 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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