eF-site ID 4qo8-D PDB Code 4qo8 Chain D click to enlarge Title Lactate Dehydrogenase A in complex with substituted 3-Hydroxy-2-mercaptocyclohex-2-enone compound 104 Classification oxidoreductase/oxidoreductase inhibitor Compound L-lactate dehydrogenase A chain Source Homo sapiens (Human) (LDHA_HUMAN) Sequence D:  ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILM KDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGK DYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFII PNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGS GCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVW SGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEV IKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLY GIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSAD TLWGIQKELQF Description Functional site 1) chain D residue 185 type sequence H description BINDING SITE FOR RESIDUE SO4 B 804 source : AC8 2) chain D residue 28 type sequence G description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 3) chain D residue 29 type sequence A description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 4) chain D residue 30 type sequence V description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 5) chain D residue 51 type sequence D description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 6) chain D residue 52 type sequence V description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 7) chain D residue 53 type sequence I description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 8) chain D residue 94 type sequence T description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 9) chain D residue 95 type sequence A description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 10) chain D residue 115 type sequence I description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 11) chain D residue 119 type sequence I description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 12) chain D residue 135 type sequence V description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 13) chain D residue 137 type sequence N description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 14) chain D residue 160 type sequence S description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 15) chain D residue 192 type sequence H description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 16) chain D residue 247 type sequence T description BINDING SITE FOR RESIDUE NAI D 801 source : BC4 17) chain D residue 170 type sequence R description BINDING SITE FOR RESIDUE SO4 D 802 source : BC5 18) chain D residue 185 type sequence H description BINDING SITE FOR RESIDUE SO4 D 802 source : BC5 19) chain D residue 137 type sequence N description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 20) chain D residue 165 type sequence D description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 21) chain D residue 168 type sequence R description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 22) chain D residue 192 type sequence H description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 23) chain D residue 193 type sequence G description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 24) chain D residue 237 type sequence A description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 25) chain D residue 238 type sequence Y description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 26) chain D residue 241 type sequence I description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 27) chain D residue 247 type sequence T description BINDING SITE FOR RESIDUE 36U D 803 source : BC6 28) chain D residue 192 type ACT_SITE sequence H description Proton acceptor source Swiss-Prot : SWS_FT_FI1 29) chain D residue 223 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI10 30) chain D residue 231 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI10 31) chain D residue 242 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI10 32) chain D residue 238 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI11 33) chain D residue 28 type BINDING sequence G description BINDING => ECO:0000269|PubMed:11276087 source Swiss-Prot : SWS_FT_FI2 34) chain D residue 98 type BINDING sequence R description BINDING => ECO:0000269|PubMed:11276087 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 105 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 36) chain D residue 137 type BINDING sequence N description source Swiss-Prot : SWS_FT_FI3 37) chain D residue 168 type BINDING sequence R description source Swiss-Prot : SWS_FT_FI3 38) chain D residue 247 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI3 39) chain D residue 1 type MOD_RES sequence A description N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895 source Swiss-Prot : SWS_FT_FI4 40) chain D residue 308 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P04642 source Swiss-Prot : SWS_FT_FI12 41) chain D residue 321 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P04642 source Swiss-Prot : SWS_FT_FI12 42) chain D residue 309 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 source Swiss-Prot : SWS_FT_FI13 43) chain D residue 56 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI14 44) chain D residue 56 type MOD_RES sequence K description N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI9 45) chain D residue 4 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI5 46) chain D residue 117 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI5 47) chain D residue 317 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P06151 source Swiss-Prot : SWS_FT_FI5 48) chain D residue 9 type MOD_RES sequence Y description Phosphotyrosine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI6 49) chain D residue 13 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI7 50) chain D residue 80 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI7 51) chain D residue 125 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI7 52) chain D residue 17 type MOD_RES sequence T description Phosphothreonine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI8

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