eF-site ID 4qin-A PDB Code 4qin Chain A click to enlarge Title Structure of the human smoothened receptor in complex with SAG1.5 Classification SIGNALING PROTEIN Compound Smoothened homolog/Soluble cytochrome b562 chimeric protein Source Homo sapiens (Human) (SMO_HUMAN) Sequence A:  QCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMH SYIAAFGAVTGLCTLFTLATFVADWRNSNRYPAVILFYVN ACFFVGSIGWLAQFMDGARREIVCRADGTMRLGEPTSNET LSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQ PLSGKTSYFHLLTWSLPFVLTVAILAVAQVDGDSVSGICF VGYKNYRYRAGFVLAPIGLVLIVGGYFLIRGVMTLFSIKS NHADLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAAL DAQKATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKL ANEGKVKEAQAAAEQLKTTRNAYIQKYLAASKINETMLRL GIFGFLAFGFVLITFSCHFYDFFNQAEWERSFRDYVLCQA NDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKATLLI WRRTWCR Description Functional site 1) chain A residue 219 type sequence N description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 2) chain A residue 220 type sequence P description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 3) chain A residue 221 type sequence L description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 4) chain A residue 222 type sequence F description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 5) chain A residue 301 type sequence M description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 6) chain A residue 383 type sequence G description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 7) chain A residue 384 type sequence D description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 8) chain A residue 394 type sequence Y description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 9) chain A residue 395 type sequence K description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 10) chain A residue 470 type sequence H description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 11) chain A residue 473 type sequence D description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 12) chain A residue 477 type sequence Q description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 13) chain A residue 480 type sequence W description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 14) chain A residue 481 type sequence E description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 15) chain A residue 484 type sequence F description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 16) chain A residue 513 type sequence P description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 17) chain A residue 518 type sequence E description BINDING SITE FOR RESIDUE SG8 A 1201 source : AC1 18) chain A residue 452-472 type TRANSMEM sequence LGIFGFLAFGFVLITFSCHFY description Helical; Name=6 => ECO:0000255 source Swiss-Prot : SWS_FT_FI8 19) chain A residue 309 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI11 20) chain A residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI12 21) chain A residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI12 22) chain A residue 394 type BINDING sequence Y description BINDING => ECO:0000250|UniProtKB:P56726 source Swiss-Prot : SWS_FT_FI10 23) chain A residue 234-254 type TRANSMEM sequence IAAFGAVTGLCTLFTLATFVA description Helical; Name=1 => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 255-262 type TOPO_DOM sequence DWRNSNRY description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 336-358 type TOPO_DOM sequence TYAWHTSFKALGTTYQPLSGKTS description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 263-283 type TRANSMEM sequence PAVILFYVNACFFVGSIGWLA description Helical; Name=2 => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 27) chain A residue 284-314 type TOPO_DOM sequence QFMDGARREIVCRADGTMRLGEPTSNETLSC description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 28) chain A residue 380-402 type TOPO_DOM sequence QVDGDSVSGICFVGYKNYRYRAG description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 29) chain A residue 473-524 type TOPO_DOM sequence DFFNQAEWERSFRDYVLCQANDCEIKNRPSLLVEKINLFA description Extracellular => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 30) chain A residue 315-335 type TRANSMEM sequence VIIFVIVYYALMAGVVWFVVL description Helical; Name=3 => ECO:0000255 source Swiss-Prot : SWS_FT_FI5 31) chain A residue 359-379 type TRANSMEM sequence YFHLLTWSLPFVLTVAILAVA description Helical; Name=4 => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 32) chain A residue 403-423 type TRANSMEM sequence FVLAPIGLVLIVGGYFLIRGV description Helical; Name=5 => ECO:0000255 source Swiss-Prot : SWS_FT_FI7 33) chain A residue 525-545 type TRANSMEM sequence MFGTGIAMSTWVWTKATLLIW description Helical; Name=7 => ECO:0000255 source Swiss-Prot : SWS_FT_FI9

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