|
|
eF-site ID
|
4qh6-E |
|
PDB Code
|
4qh6 |
|
Chain
|
E |
|
click to enlarge
|
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Title
|
Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE |
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Classification
|
Hydrolase/Hydrolase inhibitor |
|
Compound
|
Cruzipain |
|
Source
|
Trypanosoma cruzi (CYSP_TRYCR) |
|
|
Sequence
|
E: |
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFL
AGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENN
GAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQ
DEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQL
DHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGS
NQCLVKEEASSAVVG
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
E |
| residue |
25 |
| type |
ACT_SITE |
| sequence |
C
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
E |
| residue |
162 |
| type |
ACT_SITE |
| sequence |
H
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
E |
| residue |
182 |
| type |
ACT_SITE |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
E |
| residue |
215 |
| type |
SITE |
| sequence |
G
|
| description |
Cleavage; by autolysis => ECO:0000269|PubMed:1559982
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
E |
| residue |
170 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
E |
| residue |
47 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|