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|
eF-site ID
|
4qfs-B |
|
PDB Code
|
4qfs |
|
Chain
|
B |
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click to enlarge
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Title
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Structure of AMPK in complex with Br2-A769662core activator and STAUROSPORINE inhibitor |
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Classification
|
signaling protein/inhibitor/activator |
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Compound
|
5'-AMP-activated protein kinase catalytic subunit alpha-1 |
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Source
|
Rattus norvegicus (Rat) (AAKG1_RAT) |
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|
Sequence
|
B: |
PTVFRWTGGGKEVYLSGSFNNWSKLPLTRDQNNFVAILDL
PEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKT
DFEVFDALMVDSQKAPPILPPHLLQVILNKCDPALLPEPN
HVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
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Description
|
(1) |
5'-AMP-activated protein kinase catalytic subunit alpha-1 (E.C.2.7.11.1, 2.7.11.27, 2.7.11.31, 2.7.11.26), 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1
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Functional site
|
|
|
1)
|
chain |
B |
| residue |
83 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE 32H A 602
|
| source |
: AC2
|
|
|
2)
|
chain |
B |
| residue |
108 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE 32H A 602
|
| source |
: AC2
|
|
|
3)
|
chain |
B |
| residue |
113 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE 32H A 602
|
| source |
: AC2
|
|
|
4)
|
chain |
B |
| residue |
85 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE CL B 301
|
| source |
: AC5
|
|
|
5)
|
chain |
B |
| residue |
136 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CL B 301
|
| source |
: AC5
|
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|
|