|
|
eF-site ID
|
4qfr-B |
|
PDB Code
|
4qfr |
|
Chain
|
B |
|
click to enlarge
|
|
|
Title
|
Structure of AMPK in complex with Cl-A769662 activator and STAUROSPORINE inhibitor |
|
Classification
|
signaling protein/inhibitor/activator |
|
Compound
|
5'-AMP-activated protein kinase catalytic subunit alpha-1 |
|
Source
|
Rattus norvegicus (Rat) (AAKG1_RAT) |
|
|
Sequence
|
B: |
PTVFRWTGGGKEVYLSGSFNNWSKLPLTRDQNNFVAILDL
PEGEHQYKFFVDGQWTHDPSEPIVTSQLGTVNNIIQVKKT
DFEVFDALMVDSQKAPPILPPHLLQVILNKSCDPALLPEP
NHVMLNHLYALSIKDGVMVLSATHRYKKKYVTTLLYKPI
|
|
|
Description
|
(1) |
5'-AMP-activated protein kinase catalytic subunit alpha-1 (E.C.2.7.11.1, 2.7.11.27, 2.7.11.31, 2.7.11.26), 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
81 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE 32J A 606
|
| source |
: AC5
|
|
|
2)
|
chain |
B |
| residue |
83 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE 32J A 606
|
| source |
: AC5
|
|
|
3)
|
chain |
B |
| residue |
107 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE 32J A 606
|
| source |
: AC5
|
|
|
4)
|
chain |
B |
| residue |
108 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE 32J A 606
|
| source |
: AC5
|
|
|
5)
|
chain |
B |
| residue |
113 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE 32J A 606
|
| source |
: AC5
|
|
|
6)
|
chain |
B |
| residue |
85 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE CL B 301
|
| source |
: AC6
|
|
|
7)
|
chain |
B |
| residue |
136 |
| type |
|
| sequence |
D
|
| description |
BINDING SITE FOR RESIDUE CL B 301
|
| source |
: AC6
|
|
|
|