eF-site ID 4qfg-A
PDB Code 4qfg
Chain A

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Title Structure of AMPK in complex with STAUROSPORINE inhibitor and in the absence of a synthetic activator
Classification signaling protein/inhibitor
Compound 5'-AMP-activated protein kinase catalytic subunit alpha-1
Source Rattus norvegicus (Rat) (AAKG1_RAT)
Sequence A:  GRVKIGHYILGDTLGVGTFGKVKVGKHELTGHKVAVKILN
RQKIRSLDVVGKIRREIQNLKLFRHPHIIKLYQVISTPSD
IFMVMEYVSGGELFDYICKNGRLDEKESRRLFQQILSGVD
YCHRHMVVHRDLKPENVLLDAHMNAKIADFGLSNMMSDGE
FLRXSCGSPNYAAPEVISGRLYAGPEVDIWSSGVILYALL
CGTLPFDDDHVPTLFKKICDGIFYTPQYLNPSVISLLKHM
LQVDPMKRATIKDIREHEWFKQDLPKYLFPWHLGIRSQSR
PNDIMAEVCRAIKQLDYEWKVVNPYYLRVRRKNPVTSTFS
KMSLQLYQVDSRTYLLDFRSIDDERPGSHTIEFFEMCANL
IKILAQ
Description (1)  5'-AMP-activated protein kinase catalytic subunit alpha-1 (E.C.2.7.11.1, 2.7.11.27, 2.7.11.31, 2.7.11.26), 5'-AMP-activated protein kinase subunit beta-1, 5'-AMP-activated protein kinase subunit gamma-1


Functional site

1) chain A
residue 22
type
sequence L
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

2) chain A
residue 23
type
sequence G
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

3) chain A
residue 25
type
sequence G
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

4) chain A
residue 30
type
sequence V
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

5) chain A
residue 43
type
sequence A
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

6) chain A
residue 77
type
sequence I
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

7) chain A
residue 94
type
sequence E
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

8) chain A
residue 95
type
sequence Y
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

9) chain A
residue 96
type
sequence V
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

10) chain A
residue 99
type
sequence G
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

11) chain A
residue 100
type
sequence E
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

12) chain A
residue 143
type
sequence E
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

13) chain A
residue 144
type
sequence N
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

14) chain A
residue 146
type
sequence L
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

15) chain A
residue 156
type
sequence A
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

16) chain A
residue 157
type
sequence D
description BINDING SITE FOR RESIDUE STU A 601
source : AC1

17) chain A
residue 24
type
sequence V
description BINDING SITE FOR RESIDUE CL A 602
source : AC2

18) chain A
residue 34
type
sequence K
description BINDING SITE FOR RESIDUE CL A 603
source : AC3

19) chain A
residue 41
type
sequence K
description BINDING SITE FOR RESIDUE CL A 603
source : AC3

20) chain A
residue 97
type
sequence S
description BINDING SITE FOR RESIDUE CL A 604
source : AC4

21) chain A
residue 149
type
sequence A
description BINDING SITE FOR RESIDUE CL A 604
source : AC4

22) chain A
residue 29
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 605
source : AC5

23) chain A
residue 48
type
sequence N
description BINDING SITE FOR RESIDUE SO4 A 605
source : AC5

24) chain A
residue 51
type
sequence K
description BINDING SITE FOR RESIDUE SO4 A 605
source : AC5

25) chain A
residue 532
type MOD_RES
sequence T
description Phosphoserine => ECO:0000269|PubMed:12764152, ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI12

26) chain A
residue 22-45
type prosite
sequence LGVGTFGKVKVGKHELTGHKVAVK
description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGVGTFGKVKvGkheltghk..........VAVK
source prosite : PS00107

27) chain A
residue 135-147
type prosite
sequence VVHRDLKPENVLL
description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvHrDLKpeNVLL
source prosite : PS00108

28) chain A
residue 456
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:Q13131
source Swiss-Prot : SWS_FT_FI6

29) chain A
residue 544
type MOD_RES
sequence K
description Phosphoserine => ECO:0000250|UniProtKB:Q13131
source Swiss-Prot : SWS_FT_FI6


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