eF-site ID 4qd2-J PDB Code 4qd2 Chain J click to enlarge Title Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex Classification CELL ADHESION Compound Hemagglutinin component HA33 Source Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) (CADH1_MOUSE) Sequence J:  WVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQ GADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAV SSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGA VPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKN MFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGL STTAKAVITVKD Description Functional site 1) chain J residue 11 type sequence E description BINDING SITE FOR RESIDUE CA J 301 source : AC4 2) chain J residue 67 type sequence D description BINDING SITE FOR RESIDUE CA J 301 source : AC4 3) chain J residue 69 type sequence E description BINDING SITE FOR RESIDUE CA J 301 source : AC4 4) chain J residue 103 type sequence D description BINDING SITE FOR RESIDUE CA J 301 source : AC4 5) chain J residue 11 type sequence E description BINDING SITE FOR RESIDUE CA J 302 source : AC5 6) chain J residue 69 type sequence E description BINDING SITE FOR RESIDUE CA J 302 source : AC5 7) chain J residue 100 type sequence D description BINDING SITE FOR RESIDUE CA J 302 source : AC5 8) chain J residue 101 type sequence Q description BINDING SITE FOR RESIDUE CA J 302 source : AC5 9) chain J residue 103 type sequence D description BINDING SITE FOR RESIDUE CA J 302 source : AC5 10) chain J residue 104 type sequence N description BINDING SITE FOR RESIDUE CA J 302 source : AC5 11) chain J residue 136 type sequence D description BINDING SITE FOR RESIDUE CA J 302 source : AC5 12) chain J residue 102 type sequence N description BINDING SITE FOR RESIDUE CA J 303 source : AC6 13) chain J residue 104 type sequence N description BINDING SITE FOR RESIDUE CA J 303 source : AC6 14) chain J residue 134 type sequence D description BINDING SITE FOR RESIDUE CA J 303 source : AC6 15) chain J residue 136 type sequence D description BINDING SITE FOR RESIDUE CA J 303 source : AC6 16) chain J residue 143 type sequence N description BINDING SITE FOR RESIDUE CA J 303 source : AC6 17) chain J residue 195 type sequence D description BINDING SITE FOR RESIDUE CA J 303 source : AC6 18) chain J residue 103 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 19) chain J residue 134 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 20) chain J residue 126 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:28973932 source Swiss-Prot : SWS_FT_FI2 21) chain J residue 131 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:28973932 source Swiss-Prot : SWS_FT_FI2 22) chain J residue 204 type CARBOHYD sequence T description O-linked (Man...) threonine => ECO:0000269|PubMed:28973932 source Swiss-Prot : SWS_FT_FI3

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