eF-site ID 4qd2-E PDB Code 4qd2 Chain E click to enlarge Title Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex Classification CELL ADHESION Compound Hemagglutinin component HA33 Source Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A) (CADH1_MOUSE) Sequence E:  WVIPPISCPENEKGEFPKNLVQIKSNRDKETKVFYSITGQ GADKPPVGVFIIERETGWLKVTQPLDREAIAKYILYSHAV SSNGEAVEDPMEIVITVTDQNDNRPEFTQEVFEGSVAEGA VPGTSVMKVSATDADDDVNTYNAAIAYTIVSQDPELPHKN MFTVNRDTGVISVLTSGLDRESYPTYTLVVQAADLQGEGL STTAKAVITVKD Description Functional site 1) chain E residue 11 type sequence E description BINDING SITE FOR RESIDUE CA E 301 source : AC1 2) chain E residue 67 type sequence D description BINDING SITE FOR RESIDUE CA E 301 source : AC1 3) chain E residue 69 type sequence E description BINDING SITE FOR RESIDUE CA E 301 source : AC1 4) chain E residue 103 type sequence D description BINDING SITE FOR RESIDUE CA E 301 source : AC1 5) chain E residue 11 type sequence E description BINDING SITE FOR RESIDUE CA E 302 source : AC2 6) chain E residue 69 type sequence E description BINDING SITE FOR RESIDUE CA E 302 source : AC2 7) chain E residue 100 type sequence D description BINDING SITE FOR RESIDUE CA E 302 source : AC2 8) chain E residue 101 type sequence Q description BINDING SITE FOR RESIDUE CA E 302 source : AC2 9) chain E residue 103 type sequence D description BINDING SITE FOR RESIDUE CA E 302 source : AC2 10) chain E residue 136 type sequence D description BINDING SITE FOR RESIDUE CA E 302 source : AC2 11) chain E residue 102 type sequence N description BINDING SITE FOR RESIDUE CA E 303 source : AC3 12) chain E residue 104 type sequence N description BINDING SITE FOR RESIDUE CA E 303 source : AC3 13) chain E residue 134 type sequence D description BINDING SITE FOR RESIDUE CA E 303 source : AC3 14) chain E residue 136 type sequence D description BINDING SITE FOR RESIDUE CA E 303 source : AC3 15) chain E residue 143 type sequence N description BINDING SITE FOR RESIDUE CA E 303 source : AC3 16) chain E residue 195 type sequence D description BINDING SITE FOR RESIDUE CA E 303 source : AC3 17) chain E residue 96-106 type prosite sequence ITVTDQNDNRP description CADHERIN_1 Cadherin domain signature. ItVtDqNDNrP source prosite : PS00232 18) chain E residue 103 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 19) chain E residue 134 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI1 20) chain E residue 126 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:28973932 source Swiss-Prot : SWS_FT_FI2 21) chain E residue 131 type CARBOHYD sequence S description O-linked (Man...) serine => ECO:0000269|PubMed:28973932 source Swiss-Prot : SWS_FT_FI2 22) chain E residue 204 type CARBOHYD sequence T description O-linked (Man...) threonine => ECO:0000269|PubMed:28973932 source Swiss-Prot : SWS_FT_FI3

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