eF-site ID 4qbz-AB PDB Code 4qbz Chain A, B click to enlarge Title Crystal structure of human TLR8 in complex with DS-802 Classification RNA BINDING PROTEIN Compound Toll-like receptor 8 Source (TLR8_HUMAN) Sequence A:  SRSYPCDEKKQNDSVIAECSNRRLQEVPQTVGKYVTELDL SDNFITHITNESFQGLQNLTKINLNHNPNVGLNITDGAFL NLKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNIT KEGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTN LELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDF KGLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFA FQNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNY LVGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRN FSKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLG INFIKQIDFKLFQNFSNLEIIYLSENRISPLVTDFEFDPH SNFYHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENL PDIACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDF DNASALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFT NLKVLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILW NDDDNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPA SLTELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLT DSLSDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLS SNLLKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFR RWMDEHLNVKIPRLVDVICASPGDQRGKSIVSLE B:  SRSYPCDEKKQVIAECSNRRLQEVPQTVGKYVTELDLSDN FITHITNESFQGLQNLTKINLNHNPNVQNGLNITDGAFLN LKNLRELLLEDNQLPQIPSGLPESLTELSLIQNNIYNITK EGISRLINLKNLYLAWNCYFNKVCEKTNIEDGVFETLTNL ELLSLSFNSLSHVPPKLPSSLRKLFLSNTQIKYISEEDFK GLINLTLLDLSGNCPRCFNAPFPCVPCDGGASINIDRFAF QNLTQLRYLNLSSTSLRKINAAWFKNMPHLKVLDLEFNYL VGEIASGAFLTMLPRLEILDLSFNYIKGSYPQHINISRNF SKLLSLRALHLRGYVFQELREDDFQPLMQLPNLSTINLGI NFIKQIDFKLFQNFSNLEIIYLSENRISPLVFEFDPHSNF YHFTRPLIKPQCAAYGKALDLSLNSIFFIGPNQFENLPDI ACLNLSANSNAQVLSGTEFSAIPHVKYLDLTNNRLDFDNA SALTELSDLEVLDLSYNSHYFRIAGVTHHLEFIQNFTNLK VLNLSHNNIYTLTDKYNLESKSLVELVFSGNRLDILWNDD DNRYISIFKGLKNLTRLDLSLNRLKHIPNEAFLNLPASLT ELHINDNMLKFFNWTLLQQFPRLELLDLRGNKLLFLTDSL SDFTSSLRTLLLSHNRISHLPSGFLSEVSSLKHLDLSSNL LKTINKSALETKTTTKLSMLELHGNPFECTCDIGDFRRWM DEHLNVKIPRLVDVICASPGDQRGKSIVSLE Description (1)  Toll-like receptor 8 Functional site 1) chain A residue 582 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 2) chain A residue 752 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 3) chain B residue 115 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 160 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 5) chain B residue 247 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 285 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 7) chain B residue 358 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 42 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 9) chain B residue 362 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 10) chain B residue 416 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 582 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 752 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 115 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 14) chain A residue 160 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 247 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 285 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 358 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 18) chain A residue 362 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 416 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 80 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 88 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 22) chain B residue 80 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 88 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 293 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 511 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 26) chain B residue 546 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 27) chain B residue 590 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 28) chain B residue 640 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 680 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 30) chain A residue 395 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 31) chain A residue 511 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 32) chain A residue 546 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 33) chain A residue 590 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 34) chain A residue 640 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 35) chain A residue 680 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 36) chain B residue 293 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4 37) chain B residue 395 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:23520111 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links