eF-site ID 4qag-B PDB Code 4qag Chain B click to enlarge Title Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase Classification HYDROLASE/HYDROLASE INHIBITOR Compound Reverse transcriptase/ribonuclease H Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1) Sequence B:  LWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQ KVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALG IIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGG NEQVDKLVSAGIR Description Functional site 1) chain B residue 443 type sequence D description BINDING SITE FOR RESIDUE MN B 601 source : AC4 2) chain B residue 549 type sequence D description BINDING SITE FOR RESIDUE MN B 601 source : AC4 3) chain B residue 443 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC5 4) chain B residue 478 type sequence E description BINDING SITE FOR RESIDUE MN B 602 source : AC5 5) chain B residue 498 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC5 6) chain B residue 443 type sequence D description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 7) chain B residue 478 type sequence E description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 8) chain B residue 498 type sequence D description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 9) chain B residue 499 type sequence S description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 10) chain B residue 539 type sequence H description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 11) chain B residue 549 type sequence D description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 12) chain B residue 443 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 478 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 14) chain B residue 498 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 549 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 16) chain B residue 440 type SITE sequence F description Cleavage; by viral protease; partial source Swiss-Prot : SWS_FT_FI2

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