eF-site ID 4qag-AB PDB Code 4qag Chain A, B click to enlarge Title Structure of a dihydroxycoumarin active-site inhibitor in complex with the RNASE H domain of HIV-1 reverse transcriptase Classification HYDROLASE/HYDROLASE INHIBITOR Compound Reverse transcriptase/ribonuclease H Source Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) (POL_HV1B1) Sequence A:  LWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQ KVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALG IIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGG NEQVDKLVSAGIR B:  LWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQ KVVPLTNTTNQKTELQAIYLALQDSGLEVNIVTDSQYALG IIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHKGIGG NEQVDKLVSAGIR Description Functional site 1) chain A residue 443 type sequence D description BINDING SITE FOR RESIDUE MN A 601 source : AC1 2) chain A residue 549 type sequence D description BINDING SITE FOR RESIDUE MN A 601 source : AC1 3) chain A residue 443 type sequence D description BINDING SITE FOR RESIDUE MN A 602 source : AC2 4) chain A residue 478 type sequence E description BINDING SITE FOR RESIDUE MN A 602 source : AC2 5) chain A residue 498 type sequence D description BINDING SITE FOR RESIDUE MN A 602 source : AC2 6) chain A residue 443 type sequence D description BINDING SITE FOR RESIDUE F95 A 603 source : AC3 7) chain A residue 478 type sequence E description BINDING SITE FOR RESIDUE F95 A 603 source : AC3 8) chain A residue 498 type sequence D description BINDING SITE FOR RESIDUE F95 A 603 source : AC3 9) chain A residue 499 type sequence S description BINDING SITE FOR RESIDUE F95 A 603 source : AC3 10) chain A residue 539 type sequence H description BINDING SITE FOR RESIDUE F95 A 603 source : AC3 11) chain A residue 549 type sequence D description BINDING SITE FOR RESIDUE F95 A 603 source : AC3 12) chain B residue 443 type sequence D description BINDING SITE FOR RESIDUE MN B 601 source : AC4 13) chain B residue 549 type sequence D description BINDING SITE FOR RESIDUE MN B 601 source : AC4 14) chain B residue 443 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC5 15) chain B residue 478 type sequence E description BINDING SITE FOR RESIDUE MN B 602 source : AC5 16) chain B residue 498 type sequence D description BINDING SITE FOR RESIDUE MN B 602 source : AC5 17) chain B residue 443 type sequence D description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 18) chain B residue 478 type sequence E description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 19) chain B residue 498 type sequence D description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 20) chain B residue 499 type sequence S description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 21) chain B residue 539 type sequence H description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 22) chain B residue 549 type sequence D description BINDING SITE FOR RESIDUE F95 B 603 source : AC6 23) chain A residue 478 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 498 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 25) chain A residue 549 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 26) chain B residue 443 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 27) chain B residue 478 type BINDING sequence E description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 28) chain B residue 498 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 29) chain B residue 549 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 30) chain A residue 443 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 31) chain A residue 440 type SITE sequence F description Cleavage; by viral protease; partial source Swiss-Prot : SWS_FT_FI2 32) chain B residue 440 type SITE sequence F description Cleavage; by viral protease; partial source Swiss-Prot : SWS_FT_FI2

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