eF-site ID 4qa7-A PDB Code 4qa7 Chain A click to enlarge Title Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate Classification HYDROLASE Compound Histone deacetylase 8 Source Homo sapiens (Human) (4QA7) Sequence A:  SLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHK QMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPD SIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCK VAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERI LYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTG DVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVY QAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYIL QWQLATLILGGGGFNLANTARCWTYLTGVILGKTLSSEIP DREFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGN LKHVV Description Functional site 1) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 2) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 3) chain A residue 267 type sequence D description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 4) chain A residue 176 type sequence D description BINDING SITE FOR RESIDUE K A 402 source : AC2 5) chain A residue 178 type sequence D description BINDING SITE FOR RESIDUE K A 402 source : AC2 6) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE K A 402 source : AC2 7) chain A residue 199 type sequence S description BINDING SITE FOR RESIDUE K A 402 source : AC2 8) chain A residue 200 type sequence L description BINDING SITE FOR RESIDUE K A 402 source : AC2 9) chain A residue 189 type sequence F description BINDING SITE FOR RESIDUE K A 403 source : AC3 10) chain A residue 192 type sequence T description BINDING SITE FOR RESIDUE K A 403 source : AC3 11) chain A residue 195 type sequence V description BINDING SITE FOR RESIDUE K A 403 source : AC3 12) chain A residue 225 type sequence Y description BINDING SITE FOR RESIDUE K A 403 source : AC3 13) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 14) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 15) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 16) chain A residue 101 type sequence D description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 17) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 18) chain A residue 152 type sequence F description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 19) chain A residue 273 type sequence P description BINDING SITE FOR RESIDUE MCM B 601 source : AC4 20) chain A residue 145 type sequence K description BINDING SITE FOR RESIDUE GOL B 602 source : AC5 21) chain A residue 148 type sequence E description BINDING SITE FOR RESIDUE GOL B 602 source : AC5 22) chain A residue 208 type sequence F description BINDING SITE FOR RESIDUE GOL B 602 source : AC5 23) chain A residue 143 type ACT_SITE sequence H description Proton acceptor => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 101 type BINDING sequence D description BINDING => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 151 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI2 26) chain A residue 306 type BINDING sequence F description BINDING => ECO:0000269|PubMed:19053282 source Swiss-Prot : SWS_FT_FI2 27) chain A residue 267 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17721440 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 178 type BINDING sequence D description BINDING => ECO:0000269|PubMed:17721440 source Swiss-Prot : SWS_FT_FI3 29) chain A residue 180 type BINDING sequence H description BINDING => ECO:0000269|PubMed:17721440 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 39 type MOD_RES sequence S description Phosphoserine => ECO:0000269|PubMed:15242608 source Swiss-Prot : SWS_FT_FI4

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