eF-site ID 4q3w-A PDB Code 4q3w Chain A click to enlarge Title Crystal structure of C. violaceum phenylalanine hydroxylase D139E mutation Classification OXIDOREDUCTASE Compound Phenylalanine-4-hydroxylase Source (PH4H_CHRVO) Sequence A:  FVVPDITTRKNVGLSHDANDFTLPQPLDRYSAEDHATWAT LYQRQCKLLPGRACDEFLEGLERLEVDADRVPDFNKLNEK LMAATGWKIVAVPGLIPDDVFFEHLANRRFPVTWWLREPH QLDYLQEPDVFHELFGHVPLLINPVFADYLEAYGKGGVKA KALGALPMLARLYWYTVEFGLINTPAGMRIYGAGILSSKS ESIYCLDSASPNRVGFDLMRIMNTRYRIDTFQKTYFVIDS FKQLFDATAPDFAPLYLQLADAQPWGAGDIAPDDLVL Description Functional site 1) chain A residue 138 type sequence H description BINDING SITE FOR RESIDUE CO A 301 source : AC1 2) chain A residue 143 type sequence H description BINDING SITE FOR RESIDUE CO A 301 source : AC1 3) chain A residue 184 type sequence E description BINDING SITE FOR RESIDUE CO A 301 source : AC1 4) chain A residue 100 type sequence G description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 5) chain A residue 101 type sequence L description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 6) chain A residue 102 type sequence I description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 7) chain A residue 119 type sequence T description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 8) chain A residue 139 type sequence E description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 9) chain A residue 134-145 type prosite sequence PDVFHELFGHVP description BH4_AAA_HYDROXYL_1 Biopterin-dependent aromatic amino acid hydroxylases signature. PDvfHELFGHVP source prosite : PS00367 10) chain A residue 138 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 11) chain A residue 143 type BINDING sequence H description source Swiss-Prot : SWS_FT_FI1 12) chain A residue 184 type BINDING sequence E description source Swiss-Prot : SWS_FT_FI1

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