|
|
eF-site ID
|
4q2z-ABHL |
|
PDB Code
|
4q2z |
|
Chain
|
A, B, H, L |
|
click to enlarge
|
|
|
Title
|
Fab fragment of HIV vaccine-elicited CD4bs-directed antibody, GE356, from a non-human primate |
|
Classification
|
IMMUNE SYSTEM |
|
Compound
|
Heavy chain of Fab fragment of HIV vaccine-elicited CD4bs-directed antibody |
|
Source
|
(4Q2Z) |
|
|
Sequence
|
A: |
EVQLVQSGAEVKKPGSSVKVSCKASGYTFTDYYMHWVRQA
PGQGLEWMGQINPKTGGTNYAQKFQGRVTMTRDTSTSTAY
MELSSLRSEDTAIYYCARGGQRLLLLRNYYFYYWGQGVLV
TVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKRVEP
|
| B: |
QSVLTQPPSVSGAPGQKVTISCTGSSSNIGGYDVHWYQQL
PGMAPKLLIYDNNERPSGISDRFSGSKSATSASLAITGLQ
TEDEADYYCQSYDSSLNAWVFGGGTRLTVLGQPKAAPSVT
LFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT
HEGSTVEKTVAP
|
| H: |
EVQLVQSGAEVKKPGSSVKVSCKASGYTFTDYYMHWVRQA
PGQGLEWMGQINPKTGGTNYAQKFQGRVTMTRDTSTSTAY
MELSSLRSEDTAIYYCARGGQRLLLLRNYYFYYWGQGVLV
TVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEP
VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSL
GTQTYICNVNHKPSNTKVDKRVEP
|
| L: |
QSVLTQPPSVSGAPGQKVTISCTGSSSNIGGYDVHWYQQL
PGMAPKLLIYDNNERPSGISDRFSGSKSATSASLAITGLQ
TEDEADYYCQSYDSSLNAWVFGGGTRLTVLGQPKAAPSVT
LFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVK
AGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVT
HEGSTVEKTVAP
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
L |
| residue |
191-197 |
| type |
prosite |
| sequence |
YSCQVTH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
|
| source |
prosite : PS00290
|
|
|
2)
|
chain |
H |
| residue |
194-200 |
| type |
prosite |
| sequence |
YICNVNH
|
| description |
IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCQVTH
|
| source |
prosite : PS00290
|
|
|
|