eF-site ID 4q21-A PDB Code 4q21 Chain A click to enlarge Title MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS Classification ONCOGENE PROTEIN Compound C-H-RAS P21 PROTEIN CATALYTIC DOMAIN Source Homo sapiens (Human) (RASH_HUMAN) Sequence A:  MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSY RKQVVIDGETCLLDILDTAGQEEYSAMRDQYMRTGEGFLC VFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV REIRQHKLR Description Functional site 1) chain A residue 17 type sequence S description BINDING SITE FOR RESIDUE MG A 273 source : AC1 2) chain A residue 12 type sequence G description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 3) chain A residue 13 type sequence G description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 4) chain A residue 15 type sequence G description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 5) chain A residue 16 type sequence K description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 6) chain A residue 17 type sequence S description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 7) chain A residue 18 type sequence A description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 8) chain A residue 28 type sequence F description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 9) chain A residue 30 type sequence D description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 10) chain A residue 116 type sequence N description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 11) chain A residue 117 type sequence K description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 12) chain A residue 119 type sequence D description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 13) chain A residue 120 type sequence L description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 14) chain A residue 145 type sequence S description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 15) chain A residue 146 type sequence A description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 16) chain A residue 147 type sequence K description BINDING SITE FOR RESIDUE GDP A 274 source : AC2 17) chain A residue 2 type MOD_RES sequence T description N-acetylthreonine; in GTPase HRas, N-terminally processed => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI3 18) chain A residue 35 type CARBOHYD sequence T description (Microbial infection) O-linked (Glc) threonine; by P.sordellii toxin TcsL => ECO:0000269|PubMed:19744486, ECO:0000269|PubMed:8626575, ECO:0000269|PubMed:8626586, ECO:0000269|PubMed:9632667 source Swiss-Prot : SWS_FT_FI9 19) chain A residue 13 type BINDING sequence G description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 20) chain A residue 29 type BINDING sequence V description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 59 type BINDING sequence A description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 22) chain A residue 116 type BINDING sequence N description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 23) chain A residue 145 type BINDING sequence S description BINDING => ECO:0000269|PubMed:16698776 source Swiss-Prot : SWS_FT_FI1 24) chain A residue 1 type MOD_RES sequence M description N-acetylmethionine; in GTPase HRas; alternate => ECO:0000269|Ref.12 source Swiss-Prot : SWS_FT_FI2 25) chain A residue 118 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:9020151 source Swiss-Prot : SWS_FT_FI4

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