eF-site ID 4q0c-ABCD PDB Code 4q0c Chain A, B, C, D click to enlarge Title 3.1 A resolution crystal structure of the B. pertussis BvgS periplasmic domain Classification TRANSFERASE Compound Virulence sensor protein BvgS Source Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) (BVGS_BORPE) Sequence A:  SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHPVVKVA VLNLFAPFTLFRTDEQFGGISAAVLQLLQLRTGLDFEIIG VDTVEELIAKLRSGEADMAGALFVNSARESFLSFSRPYVR NGMVIVTRQDPDAPVDADHLDGRTVALVRNSAAIPLLQRR YPQAKVVTADNPSEAMLMVANGQADAVVQTQISASYYVNR YFAGKLRIASALDLPPAEIALATTRGQTELMSILNKALYS ISNDELASIISRWRGSDGDPRTWYAYRNEIYLE B:  SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHPVVKVA VLNLFAPFTLFRTDEQFGGISAAVLQLLQLRTGLDFEIIG VDTVEELIAKLRSGEADMAGALFVNSARESFLSFSRPYVR NGMVIVTRQDPDAPVDADHLDGRTVALVRNSAAIPLLQRR YPQAKVVTADNPSEAMLMVANGQADAVVQTQISASYYVNR YFAGKLRIASALDLPPAEIALATTRGQTELMSILNKALYS ISNDELASIISRWRGSDGDPRTWYAYRNEIYLE C:  SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHPVVKVA VLNLFAPFTLFRTDEQFGGISAAVLQLLQLRTGLDFEIIG VDTVEELIAKLRSGEADMAGALFVNSARESFLSFSRPYVR NGMVIVTRQDPDAPVDADHLDGRTVALVRNSAAIPLLQRR YPQAKVVTADNPSEAMLMVANGQADAVVQTQISASYYVNR YFAGKLRIASALDLPPAEIALATTRGQTELMSILNKALYS ISNDELASIISRWRGSDGDPRTWYAYRNEIYLE D:  SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHPVVKVA VLNLFAPFTLFRTDEQFGGISAAVLQLLQLRTGLDFEIIG VDTVEELIAKLRSGEADMAGALFVNSARESFLSFSRPYVR NGMVIVTRQDPDAPVDADHLDGRTVALVRNSAAIPLLQRR YPQAKVVTADNPSEAMLMVANGQADAVVQTQISASYYVNR YFAGKLRIASALDLPPAEIALATTRGQTELMSILNKALYS ISNDELASIISRWRGSDGDPRTWYAYRNEIYLE Description Functional site 1) chain A residue 33-307 type TOPO_DOM sequence SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHP description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 2) chain B residue 33-307 type TOPO_DOM sequence SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHP description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 33-307 type TOPO_DOM sequence SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHP description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 4) chain D residue 33-307 type TOPO_DOM sequence SQELTLVGKAAVPDVEVALDGDDWRWLARKRVLTLGVYAP DIPPFDVTYGERYEGLTADYMAIIAHNLGMQAKVLRYPTR EQALSALESGQIDLIGTVNGTDGRQQSLRLSVPYAADHPV IVMPIGARHVPASNLAGQRLAVDINYLPKETLARAYPQAT LHYFPSSEQALAAVAYGQADVFIGDALTTSHLVSQSYFND VRVVAPAHIATGGESFGVRADNTRLLRVVNAVLEAIPPSE HRSLIYRWGLGSSISLDFAHPAYSAREQQWMADHP description Cytoplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 308-331 type TRANSMEM sequence VVKVAVLNLFAPFTLFRTDEQFGG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 6) chain B residue 308-331 type TRANSMEM sequence VVKVAVLNLFAPFTLFRTDEQFGG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 7) chain C residue 308-331 type TRANSMEM sequence VVKVAVLNLFAPFTLFRTDEQFGG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 8) chain D residue 308-331 type TRANSMEM sequence VVKVAVLNLFAPFTLFRTDEQFGG description Helical => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 332-541 type TOPO_DOM sequence ISAAVLQLLQLRTGLDFEIIGVDTVEELIAKLRSGEADMA GALFVNSARESFLSFSRPYVRNGMVIVTRQDPDAPVDADH LDGRTVALVRNSAAIPLLQRRYPQAKVVTADNPSEAMLMV ANGQADAVVQTQISASYYVNRYFAGKLRIASALDLPPAEI ALATTRGQTELMSILNKALYSISNDELASIISRWRGSDGD PRTWYAYRNE description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 332-541 type TOPO_DOM sequence ISAAVLQLLQLRTGLDFEIIGVDTVEELIAKLRSGEADMA GALFVNSARESFLSFSRPYVRNGMVIVTRQDPDAPVDADH LDGRTVALVRNSAAIPLLQRRYPQAKVVTADNPSEAMLMV ANGQADAVVQTQISASYYVNRYFAGKLRIASALDLPPAEI ALATTRGQTELMSILNKALYSISNDELASIISRWRGSDGD PRTWYAYRNE description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 11) chain C residue 332-541 type TOPO_DOM sequence ISAAVLQLLQLRTGLDFEIIGVDTVEELIAKLRSGEADMA GALFVNSARESFLSFSRPYVRNGMVIVTRQDPDAPVDADH LDGRTVALVRNSAAIPLLQRRYPQAKVVTADNPSEAMLMV ANGQADAVVQTQISASYYVNRYFAGKLRIASALDLPPAEI ALATTRGQTELMSILNKALYSISNDELASIISRWRGSDGD PRTWYAYRNE description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3 12) chain D residue 332-541 type TOPO_DOM sequence ISAAVLQLLQLRTGLDFEIIGVDTVEELIAKLRSGEADMA GALFVNSARESFLSFSRPYVRNGMVIVTRQDPDAPVDADH LDGRTVALVRNSAAIPLLQRRYPQAKVVTADNPSEAMLMV ANGQADAVVQTQISASYYVNRYFAGKLRIASALDLPPAEI ALATTRGQTELMSILNKALYSISNDELASIISRWRGSDGD PRTWYAYRNE description Periplasmic => ECO:0000255 source Swiss-Prot : SWS_FT_FI3

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