eF-site ID 4pzv-A PDB Code 4pzv Chain A click to enlarge Title Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D Classification TRANSFERASE Compound 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase Source Francisella tularensis subsp. tularensis (strain SCHU S4 / Schu 4) (Q5NGA7_FRATT) Sequence A:  MQYIIGIGTNIGFTIENIHLAITALESQQNIRIIRKASLY SSKAVLKEDAPKEWDIRFLNTAVKISSSLKPDELLVLLKD IELKIGRDLNAPAWSPRVIDLDILAAEDLILETDKLTIPH KELINRSFALAPLLELSKGWHHPKYVEWDLNIRLKELGEI VKLKQTLANTIRMGIVNLSSDGNFDDNQRKLNLDELIQSG AEIIDIGAESTKPISIEEEFNKLDEFLEYFKSQLANLIYK PLVSIDTRKLEVMQKILAKHHDIIWMINDVECNNIEQKAQ LIAKYNKKYVIIHNLGITDRNQYLDKENAIDNVCDYIEQK KQILLKHGIAQQNIYFDIGFGFGKKSDTARYLLENIIEIK RRLELKALVGHSRKPSVLGLAKDSNLATLDRATRELSRKL EKLDIDIIRVHKI Description Functional site 1) chain A residue 42 type sequence S description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 2) chain A residue 43 type sequence K description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 3) chain A residue 45 type sequence V description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 4) chain A residue 58 type sequence F description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 5) chain A residue 60 type sequence N description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 6) chain A residue 75 type sequence L description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 7) chain A residue 79 type sequence K description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 8) chain A residue 87 type sequence R description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 9) chain A residue 94 type sequence W description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 10) chain A residue 97 type sequence R description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 11) chain A residue 100 type sequence D description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 12) chain A residue 102 type sequence D description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 13) chain A residue 103 type sequence I description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 14) chain A residue 115 type sequence K description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 15) chain A residue 116 type sequence L description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 16) chain A residue 117 type sequence T description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 17) chain A residue 128 type sequence F description BINDING SITE FOR RESIDUE J1D A 501 source : AC1 18) chain A residue 145 type sequence Y description BINDING SITE FOR RESIDUE EDO A 502 source : AC2 19) chain A residue 316 type sequence N description BINDING SITE FOR RESIDUE EDO A 502 source : AC2 20) chain A residue 320 type sequence N description BINDING SITE FOR RESIDUE EDO A 502 source : AC2 21) chain A residue 177 type sequence N description BINDING SITE FOR RESIDUE EDO A 503 source : AC3 22) chain A residue 215 type sequence T description BINDING SITE FOR RESIDUE EDO A 503 source : AC3 23) chain A residue 417 type sequence R description BINDING SITE FOR RESIDUE EDO A 503 source : AC3 24) chain A residue 419 type sequence H description BINDING SITE FOR RESIDUE EDO A 503 source : AC3 25) chain A residue 2 type sequence Q description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 26) chain A residue 4 type sequence I description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 27) chain A residue 64 type sequence K description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 28) chain A residue 107 type sequence E description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 29) chain A residue 137 type sequence S description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 30) chain A residue 140 type sequence W description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 31) chain A residue 77 type sequence L description BINDING SITE FOR RESIDUE EDO A 505 source : AC5 32) chain A residue 84 type sequence K description BINDING SITE FOR RESIDUE EDO A 505 source : AC5 33) chain A residue 161 type sequence V description BINDING SITE FOR RESIDUE EDO A 506 source : AC6 34) chain A residue 162 type sequence K description BINDING SITE FOR RESIDUE EDO A 506 source : AC6 35) chain A residue 164 type sequence K description BINDING SITE FOR RESIDUE EDO A 506 source : AC6 36) chain A residue 202 type sequence Q description BINDING SITE FOR RESIDUE EDO A 506 source : AC6 37) chain A residue 323 type sequence D description BINDING SITE FOR RESIDUE EDO A 507 source : AC7 38) chain A residue 326 type sequence E description BINDING SITE FOR RESIDUE EDO A 507 source : AC7 39) chain A residue 370 type sequence R description BINDING SITE FOR RESIDUE EDO A 507 source : AC7 40) chain A residue 138 type sequence K description BINDING SITE FOR RESIDUE EDO A 508 source : AC8 41) chain A residue 140 type sequence W description BINDING SITE FOR RESIDUE EDO A 508 source : AC8 42) chain A residue 141 type sequence H description BINDING SITE FOR RESIDUE EDO A 508 source : AC8 43) chain A residue 148 type sequence W description BINDING SITE FOR RESIDUE EDO A 508 source : AC8 44) chain A residue 149 type sequence D description BINDING SITE FOR RESIDUE EDO A 508 source : AC8 45) chain A residue 150 type sequence L description BINDING SITE FOR RESIDUE EDO A 508 source : AC8 46) chain A residue 151 type sequence N description BINDING SITE FOR RESIDUE EDO A 508 source : AC8

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