eF-site ID 4puf-D
PDB Code 4puf
Chain D

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Title Complex between the Salmonella T3SS effector SlrP and its human target thioredoxin-1
Classification LIGASE/OXIDOREDUCTASE
Compound E3 ubiquitin-protein ligase SlrP
Source null (THIO_HUMAN)
Sequence D:  HHHHHGSMVKQIESKTAFQEALDAAGDKLVVVDFSATWCG
PCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKC
MPTFQFFKKGQKVGEFSGANKEKLEATINELV
Description


Functional site

1) chain D
residue 32
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:9108029
source Swiss-Prot : SWS_FT_FI1

2) chain D
residue 35
type ACT_SITE
sequence C
description Nucleophile => ECO:0000269|PubMed:9108029
source Swiss-Prot : SWS_FT_FI1

3) chain D
residue 26
type SITE
sequence D
description Deprotonates C-terminal active site Cys => ECO:0000305
source Swiss-Prot : SWS_FT_FI2

4) chain D
residue 33
type SITE
sequence G
description Contributes to redox potential value => ECO:0000305
source Swiss-Prot : SWS_FT_FI3

5) chain D
residue 34
type SITE
sequence P
description Contributes to redox potential value => ECO:0000305
source Swiss-Prot : SWS_FT_FI3

6) chain D
residue 3
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

7) chain D
residue 39
type MOD_RES
sequence K
description N6-acetyllysine => ECO:0007744|PubMed:19608861
source Swiss-Prot : SWS_FT_FI4

8) chain D
residue 8
type MOD_RES
sequence K
description N6-succinyllysine => ECO:0000250|UniProtKB:P10639
source Swiss-Prot : SWS_FT_FI5

9) chain D
residue 62
type MOD_RES
sequence C
description S-nitrosocysteine => ECO:0000269|PubMed:17260951
source Swiss-Prot : SWS_FT_FI6

10) chain D
residue 69
type MOD_RES
sequence C
description S-nitrosocysteine => ECO:0000269|PubMed:17260951
source Swiss-Prot : SWS_FT_FI6

11) chain D
residue 73
type MOD_RES
sequence C
description S-nitrosocysteine; alternate => ECO:0000269|PubMed:16408020, ECO:0000269|PubMed:17606900
source Swiss-Prot : SWS_FT_FI7

12) chain D
residue 94
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P10639
source Swiss-Prot : SWS_FT_FI8


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