eF-site ID 4pqt-A
PDB Code 4pqt
Chain A

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Title Insights into the mechanism of deubiquitination by JAMM deubiquitinases from co-crystal structures of enzyme with substrate and product
Classification Hydrolase/transcription
Compound AMSH-like protease sst2
Source Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (J3QRK5_HUMAN)
Sequence A:  KIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLETC
GILCGKLRQNAFFITHLVIPLQEATSDTCGTTDEASLFEF
QDKHNLLTLGWIHTHPTQTCFMSSVALHTHCSYQLMLPEA
IAIVMAPSKNTSGIFRLLDPEGLQTIVKCRKPGLFHPHEG
KVYTMVAQPGHVREINSKLQVVDLR
Description


Functional site

1) chain A
residue 356
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

2) chain A
residue 397
type
sequence C
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

3) chain A
residue 404
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

4) chain A
residue 406
type
sequence H
description BINDING SITE FOR RESIDUE ZN A 501
source : AC1

5) chain A
residue 416
type
sequence Q
description BINDING SITE FOR RESIDUE EDO A 503
source : AC2

6) chain A
residue 417
type
sequence P
description BINDING SITE FOR RESIDUE EDO A 503
source : AC2

7) chain A
residue 418
type
sequence G
description BINDING SITE FOR RESIDUE EDO A 503
source : AC2

8) chain A
residue 341
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182
source Swiss-Prot : SWS_FT_FI1

9) chain A
residue 343
type BINDING
sequence H
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182
source Swiss-Prot : SWS_FT_FI1

10) chain A
residue 354
type BINDING
sequence A
description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182
source Swiss-Prot : SWS_FT_FI1

11) chain A
residue 356
type BINDING
sequence H
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 397
type BINDING
sequence C
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 404
type BINDING
sequence H
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 406
type BINDING
sequence H
description BINDING => ECO:0000250
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 286
type SITE
sequence E
description Indirect zinc-binding => ECO:0000250
source Swiss-Prot : SWS_FT_FI3


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