eF-site ID 4ppc-B PDB Code 4ppc Chain B click to enlarge Title ITK kinase domain with compound 27 (N-{1-[(1R)-3-(DIMETHYLAMINO)-1-PHENYLPROPYL]-1H-PYRAZOL-4-YL}-6-(1H-PYRAZOL-4-YL)-1H-INDAZOLE-3-CARBOXAMIDE) Classification transferase/transferase inhibitor Compound Tyrosine-protein kinase ITK/TSK Source Homo sapiens (Human) (ITK_HUMAN) Sequence B:  SVIDPSELTFVQEIGSGGLVHLGYWLNKDKVAIKTIIEEA EVMMKLSHPKLVQLYGVCLAPICLVFEFMEHGCLSDYLRT QRGLFAAETLLGMCLDVCEGMAYLEEACVIHRDLAARNCL VGENQVIKVSDFPVKWASPEVFSFSRYSSKSDVWSFGVLM WEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVY QIMNHCWKERPEDRPAFSRLLRQLAEIAESG Description Functional site 1) chain B residue 367 type sequence Q description BINDING SITE FOR RESIDUE 2VW A 701 source : AC1 2) chain B residue 369 type sequence I description BINDING SITE FOR RESIDUE 2VW A 701 source : AC1 3) chain B residue 389 type sequence A description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 4) chain B residue 391 type sequence K description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 5) chain B residue 419 type sequence V description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 6) chain B residue 435 type sequence F description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 7) chain B residue 436 type sequence E description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 8) chain B residue 437 type sequence F description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 9) chain B residue 438 type sequence M description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 10) chain B residue 439 type sequence E description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 11) chain B residue 441 type sequence G description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 12) chain B residue 489 type sequence L description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 13) chain B residue 499 type sequence S description BINDING SITE FOR RESIDUE 2VW B 701 source : AC2 14) chain B residue 482 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 369 type BINDING sequence I description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 391 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 17) chain B residue 565 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:19690332 source Swiss-Prot : SWS_FT_FI4

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