eF-site ID 4pnk-ABG PDB Code 4pnk Chain A, B, G click to enlarge Title G protein-coupled receptor kinase 2 in complex with GSK180736A Classification Transferase/Transferase inhibitor Compound Beta-adrenergic receptor kinase 1 Source (GBG2_BOVIN) Sequence A:  KKILLPEPSIRSVMQKYLEDRGEVTFEKIFSQKLGYLLFR DFCLNHLEEARPLVEFYEEIKKYEKLETEEERVARSREIF DSYIMKELLACSHPFSKSATEHVQGHLGKKQVPPDLFQPY IEEICQNLRGDVFQKFIESDKFTRFCQWKNVELNIHLTMN DFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKM KQGETLALNERIMLSLVSTGDCPFIVCMSYAFHTPDKLSF ILDLMNGGDLHYHLSQHGVFSEADMRFYAAEIILGLEHMH NRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHA SVGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHS PFRQHKTKDKHEIDRMTLTMAVELPDSFSPELRSLLEGLL QRDVNRRLGCLGRGAQEVKESPFFRSLDWQMVFLQKYPPP LIPPREVNATKGIKLLDSDQELYRNFPLTISERWQQEVAE TVFDTINAETDRLEARKKAKNKQLGHEEDYALGKDCIMHG YMSKMGNPFLTQWQRRYFYLFPNRLEWRGEGEAPQSLLTM EEIQSVEETQIKERKCLLLKIRGGKQFILQCDSDPELVQW KKELRDAYREAQQLVQRVPKMKNKP B:  SELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVG RIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLII WDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNIC SIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSS GDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVS GACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAF ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKS GRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVT DDGMAVATGSWDSFLKIWN G:  ASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAK EDPLLTPVPASENPFREKKFFS Description Functional site 1) chain A residue 197 type sequence I description binding site for residue KZQ A 701 source : AC1 2) chain A residue 198 type sequence G description binding site for residue KZQ A 701 source : AC1 3) chain A residue 199 type sequence R description binding site for residue KZQ A 701 source : AC1 4) chain A residue 200 type sequence G description binding site for residue KZQ A 701 source : AC1 5) chain A residue 205 type sequence V description binding site for residue KZQ A 701 source : AC1 6) chain A residue 218 type sequence A description binding site for residue KZQ A 701 source : AC1 7) chain A residue 222 type sequence L description binding site for residue KZQ A 701 source : AC1 8) chain A residue 272 type sequence D description binding site for residue KZQ A 701 source : AC1 9) chain A residue 274 type sequence M description binding site for residue KZQ A 701 source : AC1 10) chain A residue 321 type sequence A description binding site for residue KZQ A 701 source : AC1 11) chain A residue 322 type sequence N description binding site for residue KZQ A 701 source : AC1 12) chain A residue 324 type sequence L description binding site for residue KZQ A 701 source : AC1 13) chain A residue 334 type sequence S description binding site for residue KZQ A 701 source : AC1 14) chain G residue 68 type MOD_RES sequence S description Cysteine methyl ester => ECO:0000269|PubMed:1903391 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 220 type MOD_RES sequence K description Cysteine methyl ester => ECO:0000269|PubMed:1903391 source Swiss-Prot : SWS_FT_FI2 16) chain G residue 68 type LIPID sequence S description S-geranylgeranyl cysteine => ECO:0000269|PubMed:12764189, ECO:0000269|PubMed:1903391, ECO:0000269|PubMed:7626050 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 197-220 type prosite sequence IGRGGFGEVYGCRKADTGKMYAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGGFGEVYgCrkadtgkm..........YAMK source prosite : PS00107 18) chain A residue 313-325 type prosite sequence VVYRDLKPANILL description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VvYrDLKpaNILL source prosite : PS00108 19) chain B residue 70-84 type prosite sequence LVSASQDGKLIIWDS description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 20) chain B residue 157-171 type prosite sequence IVTSSGDTTCALWDI description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678 21) chain B residue 285-299 type prosite sequence LLAGYDDFNCNVWDA description WD_REPEATS_1 Trp-Asp (WD) repeats signature. LVSAsqDgKLIIWDS source prosite : PS00678

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