eF-site ID 4pjt-D PDB Code 4pjt Chain D click to enlarge Title Structure of PARP1 catalytic domain bound to inhibitor BMN 673 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Poly [ADP-ribose] polymerase 1 Source Homo sapiens (Human) (PARP1_HUMAN) Sequence D:  SKLPKPVQDLIKMIFDVESMKKAMVEYEIDLQKMPLGKLS KRQIQAAYSILSEVQQAVSLDLSNRFYTLIPHDPPLLNNA DSVQAKVEMLDNLLDIEVAYSLLRDPIDVNYEKLKTDIKV VDRDSEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREG ECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQGLRIAPPE APVTGYMFGKGIYFADMVSKSANYCHTSQGDPIGLILLGE VALGNMYELKHASHISKLPKGKHSVKGLGKTTPDPSANIS LDGVDVPLGTGISSGVNDTSLLYNEYIVYDIAQVNLKYLL KLKFNF Description Functional site 1) chain D residue 850 type sequence P description binding site for residue GOL A 1107 source : AC7 2) chain D residue 854 type sequence L description binding site for residue GOL A 1107 source : AC7 3) chain D residue 946 type sequence H description binding site for residue GOL A 1107 source : AC7 4) chain D residue 846 type sequence Q description binding site for residue SO4 C 1102 source : AD6 5) chain D residue 849 type sequence K description binding site for residue SO4 C 1102 source : AD6 6) chain D residue 842 type sequence E description binding site for residue SO4 D 1101 source : AE1 7) chain D residue 843 type sequence G description binding site for residue SO4 D 1101 source : AE1 8) chain D residue 844 type sequence E description binding site for residue SO4 D 1101 source : AE1 9) chain D residue 845 type sequence C description binding site for residue SO4 D 1101 source : AE1 10) chain D residue 846 type sequence Q description binding site for residue SO4 D 1101 source : AE1 11) chain D residue 903 type sequence K description binding site for residue SO4 D 1102 source : AE2 12) chain D residue 984 type sequence L description binding site for residue SO4 D 1102 source : AE2 13) chain D residue 985 type sequence L description binding site for residue SO4 D 1102 source : AE2 14) chain D residue 986 type sequence Y description binding site for residue SO4 D 1102 source : AE2 15) chain D residue 858 type sequence R description binding site for residue SO4 D 1103 source : AE3 16) chain D residue 929 type sequence M description binding site for residue SO4 D 1103 source : AE3 17) chain D residue 949 type sequence K description binding site for residue SO4 D 1103 source : AE3 18) chain D residue 759 type sequence Q description binding site for residue 2YQ D 1104 source : AE4 19) chain D residue 763 type sequence E description binding site for residue 2YQ D 1104 source : AE4 20) chain D residue 862 type sequence H description binding site for residue 2YQ D 1104 source : AE4 21) chain D residue 863 type sequence G description binding site for residue 2YQ D 1104 source : AE4 22) chain D residue 888 type sequence G description binding site for residue 2YQ D 1104 source : AE4 23) chain D residue 889 type sequence Y description binding site for residue 2YQ D 1104 source : AE4 24) chain D residue 896 type sequence Y description binding site for residue 2YQ D 1104 source : AE4 25) chain D residue 897 type sequence F description binding site for residue 2YQ D 1104 source : AE4 26) chain D residue 898 type sequence A description binding site for residue 2YQ D 1104 source : AE4 27) chain D residue 903 type sequence K description binding site for residue 2YQ D 1104 source : AE4 28) chain D residue 904 type sequence S description binding site for residue 2YQ D 1104 source : AE4 29) chain D residue 907 type sequence Y description binding site for residue 2YQ D 1104 source : AE4 30) chain D residue 988 type sequence E description binding site for residue 2YQ D 1104 source : AE4 31) chain D residue 988 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 862 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 33) chain D residue 871 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 34) chain D residue 878 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 904 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2

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