|
eF-site ID
|
4pgz-C |
PDB Code
|
4pgz |
Chain
|
C |
|
click to enlarge
|
|
Title
|
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation |
Classification
|
TRANSFERASE |
Compound
|
Mast/stem cell growth factor receptor Kit |
Source
|
(KIT_HUMAN) |
|
Sequence
|
C: |
DKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQW
IYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGG
TYTFLVSNSDVNAAIAFNVYVNTKPEILIRMLQCVAAGFP
EPTIDWYFCVQTLNSSGPPFGKLVVQSSICKAYNDVGKTS
AYFNF
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
C |
residue |
465 |
type |
CARBOHYD |
sequence |
S
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
2)
|
chain |
C |
residue |
320 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
3)
|
chain |
C |
residue |
352 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
4)
|
chain |
C |
residue |
367 |
type |
CARBOHYD |
sequence |
N
|
description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|