|
|
eF-site ID
|
4pgz-B |
|
PDB Code
|
4pgz |
|
Chain
|
B |
|
click to enlarge
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Title
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Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation |
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Classification
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TRANSFERASE |
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Compound
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Mast/stem cell growth factor receptor Kit |
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Source
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(KIT_HUMAN) |
|
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Sequence
|
B: |
DKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQW
IYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGG
TYTFLVSNSDVNAAIAFNVYVNTKPEILIRLVNLQCVAAG
FPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKL
VVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFN
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Description
|
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Functional site
|
|
|
1)
|
chain |
B |
| residue |
465 |
| type |
CARBOHYD |
| sequence |
S
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
2)
|
chain |
B |
| residue |
488 |
| type |
CARBOHYD |
| sequence |
T
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
320 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
352 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
367 |
| type |
CARBOHYD |
| sequence |
N
|
| description |
N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
|