eF-site ID 4pgz-ABC PDB Code 4pgz Chain A, B, C click to enlarge Title Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation Classification TRANSFERASE Compound Mast/stem cell growth factor receptor Kit Source (KIT_HUMAN) Sequence A:  VDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQ WIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEG GTYTFLVSNSDVNAAIAFNVYVNTKPEILIRLVNGMLQCV AAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPF GKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNF B:  DKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQW IYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGG TYTFLVSNSDVNAAIAFNVYVNTKPEILIRLVNLQCVAAG FPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKL VVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFN C:  DKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQW IYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGG TYTFLVSNSDVNAAIAFNVYVNTKPEILIRMLQCVAAGFP EPTIDWYFCVQTLNSSGPPFGKLVVQSSICKAYNDVGKTS AYFNF Description Functional site 1) chain C residue 320 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 2) chain C residue 352 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 3) chain C residue 367 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 320 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 352 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 367 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 7) chain B residue 320 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 8) chain B residue 352 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 9) chain B residue 367 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946 source Swiss-Prot : SWS_FT_FI1 10) chain C residue 465 type CARBOHYD sequence S description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 465 type CARBOHYD sequence S description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 488 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 13) chain B residue 465 type CARBOHYD sequence S description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2 14) chain B residue 488 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI2

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