eF-site ID 4pgz-ABC
PDB Code 4pgz
Chain A, B, C

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Title Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Classification TRANSFERASE
Compound Mast/stem cell growth factor receptor Kit
Source (KIT_HUMAN)
Sequence A:  VDKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQ
WIYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEG
GTYTFLVSNSDVNAAIAFNVYVNTKPEILIRLVNGMLQCV
AAGFPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPF
GKLVVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFNF
B:  DKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQW
IYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGG
TYTFLVSNSDVNAAIAFNVYVNTKPEILIRLVNLQCVAAG
FPEPTIDWYFCPGTEQRCSASVLPVDVQTLNSSGPPFGKL
VVQSSIDSSAFKHNGTVECKAYNDVGKTSAYFN
C:  DKGFINIFPMINTTVFVNDGENVDLIVEYEAFPKPEHQQW
IYMNRTFTDKWEDYPKSENESNIRYVSELHLTRLKGTEGG
TYTFLVSNSDVNAAIAFNVYVNTKPEILIRMLQCVAAGFP
EPTIDWYFCVQTLNSSGPPFGKLVVQSSICKAYNDVGKTS
AYFNF
Description


Functional site

1) chain C
residue 320
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

2) chain C
residue 352
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

3) chain C
residue 367
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

4) chain A
residue 320
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

5) chain A
residue 352
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 367
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

7) chain B
residue 320
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

8) chain B
residue 352
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

9) chain B
residue 367
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17662946
source Swiss-Prot : SWS_FT_FI1

10) chain C
residue 465
type CARBOHYD
sequence S
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2

11) chain A
residue 465
type CARBOHYD
sequence S
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2

12) chain A
residue 488
type CARBOHYD
sequence T
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2

13) chain B
residue 465
type CARBOHYD
sequence S
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2

14) chain B
residue 488
type CARBOHYD
sequence T
description N-linked (GlcNAc...) asparagine => ECO:0000255
source Swiss-Prot : SWS_FT_FI2


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