|
eF-site ID
|
4pd4-A |
PDB Code
|
4pd4 |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action |
Classification
|
OXIDOREDUCTASE/INHIBITOR |
Compound
|
Cytochrome b-c1 complex subunit 1, mitochondrial |
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
|
Sequence
|
A: |
AEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYN
NGVSNLWKNIFLSKENSAVAAKEGLALSSNISRDFQSYIV
SSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLK
QVQDFEDNDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLE
NLVVADLESFANNHFLNSNAVVVGTGNIKHEDLVNSIESK
NLSLQTGTKPVLKKKAAFLGSEVRLRDDTLPKAWISLAVE
GEPVNSPNYFVAKLAAQIFGSYNAFEPASRLQGIKLLDNI
QEYQLCDNFNHFSLSYKDSGLWGFSTATRNVTMIDDLIHF
TLKQWNRLTISVTDTEVERAKSLLKLQLGQLYESGNPVND
ANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRL
WDQDIAIAGTGQIEGLLDYMRIRSDMSMMRW
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
427 |
type |
|
sequence |
W
|
description |
binding site for residue UMQ A 501
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
428 |
type |
|
sequence |
D
|
description |
binding site for residue UMQ A 501
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
453 |
type |
|
sequence |
S
|
description |
binding site for residue UMQ A 501
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
454 |
type |
|
sequence |
M
|
description |
binding site for residue UMQ A 501
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
455 |
type |
|
sequence |
M
|
description |
binding site for residue UMQ A 501
|
source |
: AC1
|
|
6)
|
chain |
A |
residue |
456 |
type |
|
sequence |
R
|
description |
binding site for residue UMQ A 501
|
source |
: AC1
|
|
7)
|
chain |
A |
residue |
450 |
type |
|
sequence |
S
|
description |
binding site for residue 3PH A 502
|
source |
: AC2
|
|
|
|