eF-site ID 4pd4-D PDB Code 4pd4 Chain D click to enlarge Title Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action Classification OXIDOREDUCTASE/INHIBITOR Compound Cytochrome b-c1 complex subunit 1, mitochondrial Source ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); Sequence D:  MTAAEHGLHAPAYAWSHNGPFETFDHASIRRGYQVYREVC AACHSLDRVAWRTLVGVSHTNEEVRNMAEEFEYDDEPDEQ GNPKKRPGKLSDYIPGPYPNEQAARAANQGALPPDLSLIV KARHGGCDYIFSLLTGYPDEPPAGVALPPGSNYNPYFPGG SIAMARVLFDDMVEYEDGTPATTSQMAKDVTTFLNWCAEP EHDERKRLGLKTVIILSSLYLLSIWVKKFKWAGIKTRKFV FNPPKPRK Description Functional site 1) chain D residue 100 type sequence V description binding site for residue HEM D 401 source : AC9 2) chain D residue 101 type sequence C description binding site for residue HEM D 401 source : AC9 3) chain D residue 104 type sequence C description binding site for residue HEM D 401 source : AC9 4) chain D residue 105 type sequence H description binding site for residue HEM D 401 source : AC9 5) chain D residue 169 type sequence N description binding site for residue HEM D 401 source : AC9 6) chain D residue 172 type sequence A description binding site for residue HEM D 401 source : AC9 7) chain D residue 175 type sequence P description binding site for residue HEM D 401 source : AC9 8) chain D residue 180 type sequence I description binding site for residue HEM D 401 source : AC9 9) chain D residue 184 type sequence R description binding site for residue HEM D 401 source : AC9 10) chain D residue 190 type sequence Y description binding site for residue HEM D 401 source : AC9 11) chain D residue 191 type sequence I description binding site for residue HEM D 401 source : AC9 12) chain D residue 195 type sequence L description binding site for residue HEM D 401 source : AC9 13) chain D residue 218 type sequence F description binding site for residue HEM D 401 source : AC9 14) chain D residue 225 type sequence M description binding site for residue HEM D 401 source : AC9 15) chain D residue 228 type sequence V description binding site for residue HEM D 401 source : AC9 16) chain D residue 251 type sequence V description binding site for residue HEM D 401 source : AC9 17) chain D residue 269 type sequence L description binding site for residue 3PH E 302 source : AD2 18) chain D residue 272 type sequence K description binding site for residue 3PH E 302 source : AD2 19) chain D residue 273 type sequence T description binding site for residue 3PH E 302 source : AD2 20) chain D residue 276 type sequence I description binding site for residue 3PH E 302 source : AD2 21) chain D residue 105 type BINDING sequence H description axial binding residue => ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1KYO source Swiss-Prot : SWS_FT_FI5 22) chain D residue 225 type BINDING sequence M description axial binding residue => ECO:0000269|PubMed:10873857, ECO:0000269|PubMed:11880631, ECO:0000269|PubMed:18390544, ECO:0000269|PubMed:30598554, ECO:0007744|PDB:1EZV, ECO:0007744|PDB:1KYO source Swiss-Prot : SWS_FT_FI6

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