|
|
eF-site ID
|
4pd4-A |
|
PDB Code
|
4pd4 |
|
Chain
|
A |
|
click to enlarge
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Title
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Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action |
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Classification
|
OXIDOREDUCTASE/INHIBITOR |
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Compound
|
Cytochrome b-c1 complex subunit 1, mitochondrial |
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Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae (strain ATCC 204508 / S288c); |
|
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Sequence
|
A: |
AEVTQLSNGIVVATEHNPSAHTASVGVVFGSGAANENPYN
NGVSNLWKNIFLSKENSAVAAKEGLALSSNISRDFQSYIV
SSLPGSTDKSLDFLNQSFIQQKANLLSSSNFEATKKSVLK
QVQDFEDNDHPNRVLEHLHSTAFQNTPLSLPTRGTLESLE
NLVVADLESFANNHFLNSNAVVVGTGNIKHEDLVNSIESK
NLSLQTGTKPVLKKKAAFLGSEVRLRDDTLPKAWISLAVE
GEPVNSPNYFVAKLAAQIFGSYNAFEPASRLQGIKLLDNI
QEYQLCDNFNHFSLSYKDSGLWGFSTATRNVTMIDDLIHF
TLKQWNRLTISVTDTEVERAKSLLKLQLGQLYESGNPVND
ANLLGAEVLIKGSKLSLGEAFKKIDAITVKDVKAWAGKRL
WDQDIAIAGTGQIEGLLDYMRIRSDMSMMRW
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Description
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Functional site
|
|
|
1)
|
chain |
A |
| residue |
427 |
| type |
|
| sequence |
W
|
| description |
binding site for residue UMQ A 501
|
| source |
: AC1
|
|
|
2)
|
chain |
A |
| residue |
428 |
| type |
|
| sequence |
D
|
| description |
binding site for residue UMQ A 501
|
| source |
: AC1
|
|
|
3)
|
chain |
A |
| residue |
453 |
| type |
|
| sequence |
S
|
| description |
binding site for residue UMQ A 501
|
| source |
: AC1
|
|
|
4)
|
chain |
A |
| residue |
454 |
| type |
|
| sequence |
M
|
| description |
binding site for residue UMQ A 501
|
| source |
: AC1
|
|
|
5)
|
chain |
A |
| residue |
455 |
| type |
|
| sequence |
M
|
| description |
binding site for residue UMQ A 501
|
| source |
: AC1
|
|
|
6)
|
chain |
A |
| residue |
456 |
| type |
|
| sequence |
R
|
| description |
binding site for residue UMQ A 501
|
| source |
: AC1
|
|
|
7)
|
chain |
A |
| residue |
450 |
| type |
|
| sequence |
S
|
| description |
binding site for residue 3PH A 502
|
| source |
: AC2
|
|
|
|