|
|
eF-site ID
|
4pcf-C |
|
PDB Code
|
4pcf |
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Chain
|
C |
|
click to enlarge
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Title
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Structure-based protein engineering of a monomeric triosephosphate isomerase towards changing substrate specificity |
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Classification
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ISOMERASE |
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Compound
|
Ma18-TIM |
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Source
|
(4PCF) |
|
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Sequence
|
C: |
SKPQPIAAANWKSGSPDSLSGLIDLFNSTSINHDVQCVVA
STFVHLAMTKERLSHPKFVIAAQNAGNTDALASLKDFGVN
WIVLGHFERRWYYGETNEIVADKVAAAVASGFMVIACIGE
TLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPV
WAIGTGKVVTPQQAQEAHALIRSWVSSKIGADVAGELRIL
YGGSVNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ
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Description
|
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Functional site
|
|
|
1)
|
chain |
C |
| residue |
103 |
| type |
ACT_SITE |
| sequence |
G
|
| description |
Electrophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
C |
| residue |
175 |
| type |
ACT_SITE |
| sequence |
G
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
C |
| residue |
11 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
4)
|
chain |
C |
| residue |
13 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|